J. Jonah Jameson's spent years making Spider-Man's life difficult - but payback's a switch when he gets shackled to Spidey, who has to rescue the irascible editor from not one but TWO mad scientists! Plus: the introductions of the Fly and Jigsaw! Electro, Mysterio, Calypso, and Mesmero! And a Dr. Octopus saga so big it took two annuals to cover it! The death of a forgotten Golden Age hero and the fate of the burglar who started Spidey's career in the first place! Features first appearances by the Black Cat and Madame Web! Guest-starring Captain America, Dazzler, Dr. Strange, the Punisher, and Spider-Woman! Collects Amazing Spider-Man #186-210, Annual #13-14, and Peter Parker, Spectacular Spider-Man Annual #1.