By Thomas D. Pollard MD, William C. Earnshaw PhD FRS, Jennifer Lippincott-Schwartz PhD, Graham Johnson MA PhD CMI

Reader-friendly Cell Biology, 4th Edition, provides a concise but comprehensive foundation for students entering research or health care career paths. Award winning illustrations help readers quickly grasp general principles. The authors have thoroughly updated this popular text to provide readers with the current understanding of the principles of normal cellular function along with examples of how molecular defects predispose to human disease. Major new themes in the 4th edition include the roles of intrinsically disordered polypeptides and phase separation in cellular functions, the influence of new molecular structures on understanding mechanisms, and the impact of exciting new methods―from single cell RNA sequencing to second generation super resolution fluorescence microscopy―on advancing our understanding.Clear, readable explanations provide a concise story about how cells function at the molecular level.An intuitive chapter flow starts with genome organization, gene expression, and RNA processing as a foundation for understanding every aspect of cellular function and physiology.Brings cellular biology to life for students interested in medical science by explaining how mutations in genes can compromise virtually every cellular system and predispose to human disease. Knowledge of cell biology has led to new treatments for cancer, heart failure, cystic fibrosis, and many other diseases.Unique illustrations with realistic proportions and relationships explain every cellular process including the assembly of SARS CoV-2, the structures attaching mitotic chromosomes to microtubules, the mechanism of DNA replication and how pumps, carriers and channels orchestrate physiological processes from synaptic transmission to cellular volume regulation.Covers exciting breakthroughs such as SMC motor proteins actively organizing chromosomal DNA, TOR kinases regulating metabolism, new types of immunotherapy for cancer treatment, mechanisms regulating fast axonal transport and their relation to neurodegenerative diseases, how completion of DNA replication sets the time for cells to enter mitosis, how a cascade of signals specifies the site of cell division, and newly understood pathways of normal and pathological cell death.Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

By Steven G. Gabbe, Jennifer R. Niebyl, Joe Leigh Simpson, Mark B Landon, Henry L Galan, Eric R. M. Jauniaux, Deborah A Driscoll, Vincenzo Berghella, William A Grobman

After 30 Years, Obstetrics: Normal And Problem Pregnancies Remains Your Go-to Choice For Authoritative Guidance On Managing Today’s Obstetric Patient. International Experts Put The Latest Knowledge In This Specialty At Your Fingertips, With Current And Relevant Information On Everything From Fetal Origins Of Adult Disease, To Improving Global Maternal Health, To Important Topics In Day-to-day Obstetrical Practice. Highly Readable, Well-illustrated, And Easy To Understand, This Bestselling Obstetrics Reference Is An Ideal Tool For Residents And Clinicians. Take Advantage Of The Collective Wisdom Of Global Experts In The Field, Including Two New Editors— Drs. Vincenzo Berghella And William Grobman -- And Nearly 30 New Contributors. Gain A New Perspective On A Wide Range Of Today's Key Issues - All Evidence-based And Easy To Read. Sweeping Updates Throughout Including Four New Chapters: ‘vaginal Birth After Cesarean Delivery’; ‘placenta Accreta’; ‘obesity’; And ‘improving Global Maternal Health: Challenges And Opportunities’ New Glossary Of The Most Frequently Used Key Abbreviations For Easy Reference Expanded Use Of Bolded Statements And Key Points As Well As Additional Tables, Flow Diagrams, And Bulleted Lists Facilitates And Enhances The Mastery Of Each Chapter More Than 100 Images In The Obstetrical Ultrasound Chapter Provide An Important Resource For Normal And Abnormal Fetal Anatomy

By NORMAN

Meet the ninety year old doctor, who, with the aid of a few simple exercises, is still practising medicine. His is just one of the incredible stories brain expert Norman Doidge tells as he reveals our brain's remarkable ability to repair itself through the power of positive thought. In The Brain That Changes Itself Doidge introduces us to the fascinating stories at the cutting edge of the brain science and the emerging discipline of 'neuroplasticity' . We meet the stroke victim who unable to feed or dress himself learned to move and talk again, the woman with a rare brain condition that left her feeling as though she was perpetually falling but who through a series of exercises rewired her brain to overcome this and the maverick scientists over turning centuries of assumptions about the brain and it's capacity for renewal. Doidge shows how their incredible work is helping the blind to see, the deaf to hear and causing Nobel laureates to rethink our model of the brain.

By Henry Marsh

What is it like to be a brain surgeon? How does it feel to hold someone's life in your hands, to cut into the stuff that creates thought, feeling, and reason? How do you live with the consequences of performing a potentially lifesaving operation when it all goes wrong?In neurosurgery, more than in any other branch of medicine, the doctor's oath to "do no harm" holds a bitter irony. Operations on the brain carry grave risks. Every day, leading neurosurgeon Henry Marsh must make agonizing decisions, often in the face of great urgency and uncertainty.If you believe that brain surgery is a precise and exquisite craft, practiced by calm and detached doctors, this gripping, brutally honest account will make you think again. With astonishing compassion and candor, Marsh reveals the fierce joy of operating, the profoundly moving triumphs, the harrowing disasters, the haunting regrets, and the moments of black humor that characterize a brain surgeon's life.Do No Harm provides unforgettable insight into the countless human dramas that take place in a busy modern hospital. Above all, it is a lesson in the need for hope when faced with life's most difficult decisions.

By Matthew Walker

Sleep is one of the most important aspects of our life, health and longevity and yet it is increasingly neglected in twenty-first-century society, with devastating consequences: every major disease in the developed world - Alzheimer's, cancer, obesity, diabetes - has very strong causal links to deficient sleep.Until very recently, science had no answer to the question of why we sleep, or what good it served, or why its absence is so damaging to our health. Compared to the other basic drives in life - eating, drinking, and reproducing - the purpose of sleep remained elusive.Now, in this book, the first of its kind written by a scientific expert, Professor Matthew Walker explores twenty years of cutting-edge research to solve the mystery of why sleep matters. Looking at creatures from across the animal kingdom as well as major human studies, Why We Sleep delves in to everything from what really happens during REM sleep to how caffeine and alcohol affect sleep and why our sleep patterns change across a lifetime, transforming our appreciation of the extraordinary phenomenon that safeguards our existence.

By Daniel Lieberman

In this landmark book of popular science, Daniel E. Lieberman—chair of the department of human evolutionary biology at Harvard University and a leader in the field—gives us a lucid and engaging account of how the human body evolved over millions of years, even as it shows how the increasing disparity between the jumble of adaptations in our Stone Age bodies and advancements in the modern world is occasioning this paradox: greater longevity but increased chronic disease.   The Story of the Human Body brilliantly illuminates as never before the major transformations that contributed key adaptations to the body: the rise of bipedalism; the shift to a non-fruit-based diet; the advent of hunting and gathering, leading to our superlative endurance athleticism; the development of a very large brain; and the incipience of cultural proficiencies. Lieberman also elucidates how cultural evolution differs from biological evolution, and how our bodies were further transformed during the Agricultural and Industrial Revolutions.   While these ongoing changes have brought about many benefits, they have also created conditions to which our bodies are not entirely adapted, Lieberman argues, resulting in the growing incidence of obesity and new but avoidable diseases, such as type 2 diabetes. Lieberman proposes that many of these chronic illnesses persist and in some cases are intensifying because of “dysevolution,” a pernicious dynamic whereby only the symptoms rather than the causes of these maladies are treated. And finally—provocatively—he advocates the use of evolutionary information to help nudge, push, and sometimes even compel us to create a more salubrious environment. (With charts and line drawings throughout.)

By Abigail C. Saguy

The United States, we are told, is facing an obesity epidemic-a "battle of the bulge" of not just national, but global proportions-that requires drastic and immediate action. Experts in the media, medical science, and government alike are scrambling to find answers. What or who is responsible for this fat crisis, and what can we do to stop it?Abigail Saguy argues that these fraught and frantic debates obscure a more important question: How has fatness come to be understood as a public health crisis at all? Why, she asks, has the view of "fat" as a problem-a symptom of immorality, a medical pathology, a public health epidemic-come to dominate more positive framings of weight-as consistent with health, beauty, or a legitimate rights claim-in public discourse? Why are heavy individuals singled out for blame? And what are the consequences of understanding weight in these ways?What's Wrong with Fat? presents each of the various ways in which fat is understood in America today, examining the implications of understanding fatness as a health risk, disease, and epidemic, and revealing why we've come to understand the issue in these terms, despite considerable scientific uncertainty and debate. Saguy shows how debates over the relationship between body size and health risk take place within a larger, though often invisible, contest over whether we should understand fatness as obesity at all. Moreover, she reveals that public discussions of the "obesity crisis" do more harm than good, leading to bullying, weight-based discrimination, and misdiagnoses.Showing that the medical framing of fat is literally making us sick, What's Wrong with Fat? provides a crucial corrective to our society's misplaced obsession with weight.

By Rahul Jandial

As One Of The World's Leading Brain Surgeons, Dr Jandial Is The Last Hope For Many Patients Who Have Extreme Forms Of Cancer - Patients Who Can't Be Saved, But Deserve More Time. Life On A Knife's Edge Is His Account Of The Resilience, Courage And Belief He Has Witnessed In His Patients, And The Lessons He Has Learned From Them. Both An Unflinching Account Of Extreme Surgeries And A Profound, Moving And Introspective Memoir, This Book Reveals The Depths Of A Surgeon's Psyche Who Is Pushed To His Limits, Day In, Day Out. From Keeping A Gun Victim's Heart Pumping With His Own Hand, To Saving A Woman From Paralysis And Performing Brain Surgery While Time Is Running Out On A Haemorrhaging Patient, We See How Making Life And Death Decisions And Facing Unimaginable Pressure Has Shaped One Man's Life. In This Breathtaking Memoir, Dr Jandial Shares What He's Learned About Human Nature, From Balancing The Line Between Life And Death Everyday.

By Katherine Eban

A NEW YORK TIMES BESTSELLER * New York Times Notable Book * Best Book of the Year: New York Public Library, Kirkus Reviews, Science FridayWith a new postscript by the authorFrom an award-winning journalist, an explosive narrative investigation of the generic drug boom that reveals fraud and life-threatening dangers on a global scale—The Jungle for pharmaceuticalsMany have hailed the widespread use of generic drugs as one of the most important public-health developments of the twenty-first century. Today, almost 90 percent of our pharmaceutical market is comprised of generics, the majority of which are manufactured overseas. We have been reassured by our doctors, our pharmacists and our regulators that generic drugs are identical to their brand-name counterparts, just less expensive. But is this really true?Katherine Eban’s Bottle of Lies exposes the deceit behind generic-drug manufacturing—and the attendant risks for global health. Drawing on exclusive accounts from whistleblowers and regulators, as well as thousands of pages of confidential FDA documents, Eban reveals an industry where fraud is rampant, companies routinely falsify data, and executives circumvent almost every principle of safe manufacturing to minimize cost and maximize profit, confident in their ability to fool inspectors. Meanwhile, patients unwittingly consume medicine with unpredictable and dangerous effects.The story of generic drugs is truly global. It connects middle America to China, India, sub-Saharan Africa and Brazil, and represents the ultimate litmus test of globalization: what are the risks of moving drug manufacturing offshore, and are they worth the savings?A decade-long investigation with international sweep, high-stakes brinkmanship and big money at its core, Bottle of Lies reveals how the world’s greatest public-health innovation has become one of its most astonishing swindles.

By Jimmie C. Holland M.D et al.

Psycho-Oncology was the first comprehensive text in the field of psychosocial oncology and remains the gold standard today. Written by 67 internationally known psychiatry and palliative care experts, the resource is truly an essential reference for all providers of palliative care.Joining Oxford Medicine Online this resource offers the best quality content in an easy-to-access format. Online only benefits include downloading images and figures to PowerPoint and downloading chapters to PDF.