Recommendations based on "Patient Zero: A Curious History of the World's Worst Diseases"

Reader-friendly Cell Biology, 4th Edition, provides a concise but comprehensive foundation for students entering research or health care career paths. Award winning illustrations help readers quickly grasp general principles. The authors have thoroughly updated this popular text to provide readers with the current understanding of the principles of normal cellular function along with examples of how molecular defects predispose to human disease. Major new themes in the 4th edition include the roles of intrinsically disordered polypeptides and phase separation in cellular functions, the influence of new molecular structures on understanding mechanisms, and the impact of exciting new methods―from single cell RNA sequencing to second generation super resolution fluorescence microscopy―on advancing our understanding.Clear, readable explanations provide a concise story about how cells function at the molecular level.An intuitive chapter flow starts with genome organization, gene expression, and RNA processing as a foundation for understanding every aspect of cellular function and physiology.Brings cellular biology to life for students interested in medical science by explaining how mutations in genes can compromise virtually every cellular system and predispose to human disease. Knowledge of cell biology has led to new treatments for cancer, heart failure, cystic fibrosis, and many other diseases.Unique illustrations with realistic proportions and relationships explain every cellular process including the assembly of SARS CoV-2, the structures attaching mitotic chromosomes to microtubules, the mechanism of DNA replication and how pumps, carriers and channels orchestrate physiological processes from synaptic transmission to cellular volume regulation.Covers exciting breakthroughs such as SMC motor proteins actively organizing chromosomal DNA, TOR kinases regulating metabolism, new types of immunotherapy for cancer treatment, mechanisms regulating fast axonal transport and their relation to neurodegenerative diseases, how completion of DNA replication sets the time for cells to enter mitosis, how a cascade of signals specifies the site of cell division, and newly understood pathways of normal and pathological cell death.Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Paperback. Pub Date :2014-01-02 Pages: 336 Language: English Publisher: HarperCollins UK Sugar is toxic. addictive and everywhere So what chance do you have of living sugar-freeWith busy lives and little time left for cooking we find ourselves. relying on a diet of processed food But this is what's responsible for our chronically expanding waistlines. soaring levels of diabetes and a catalogue of diseases.Dr Robert Lustig reveals the truth about our sugar-laden food:. Why conventional low-fat weight loss advice won't work: not every calorie is the same. and skipping lunch doesn't mean it's ok to eat dessert Why too much sugar can cause serious illness even if you are not overweight How the food industry is filling our diets with hidden sugars - and which foods you must cut out to avoid themHow governments are complacent about. and even complicit in. exacerbating our food deb...

This "eye-opening and essential" book (Bill Gates) will transform how you see our biggest environmental problems—and explains how we can solve them. It’s become common to tell kids that they’re going to die from climate change. We are constantly bombarded by doomsday headlines that tell us the soil won’t be able to support crops, fish will vanish from our oceans, and that we should reconsider having children.But in this bold, radically hopeful book, data scientist Hannah Ritchie argues that if we zoom out, a very different picture emerges. In fact, the data shows we’ve made so much progress on these problems that we could be on track to achieve true sustainability for the first time in human history. Did you know that: Carbon emissions per capita are actually down Deforestation peaked back in the 1980s The air we breathe now is vastly improved from centuries ago And more people died from natural disasters a hundred years ago?Packed with the latest research, practical guidance, and enlightening graphics, this book will make you rethink almost everything you’ve been told about the environment. Not the End of the World will give you the tools to understand our current crisis and make lifestyle changes that actually have an impact. Hannah cuts through the noise by outlining what works, what doesn’t, and what we urgently need to focus on so we can leave a sustainable planet for future generations.These problems are big. But they are solvable. We are not doomed. We can build a better future for everyone. Let’s turn that opportunity into reality.

#1 NEW YORK TIMES BESTSELLER • OPRAH’S BOOK CLUB PICK • ONE OF GQ's TOP 50 BOOKS OF LITERARY JOURNALISM IN THE 21st CENTURY • The heartrending story of a midcentury American family with twelve children, six of them diagnosed with schizophrenia, that became science's great hope in the quest to understand the disease."Reads like a medical detective journey and sheds light on a topic so many of us face: mental illness." —Oprah WinfreyDon and Mimi Galvin seemed to be living the American dream. After World War II, Don's work with the Air Force brought them to Colorado, where their twelve children perfectly spanned the baby boom: the oldest born in 1945, the youngest in 1965. In those years, there was an established script for a family like the Galvins--aspiration, hard work, upward mobility, domestic harmony--and they worked hard to play their parts. But behind the scenes was a different story: psychological breakdown, sudden shocking violence, hidden abuse. By the mid-1970s, six of the ten Galvin boys, one after another, were diagnosed as schizophrenic. How could all this happen to one family?What took place inside the house on Hidden Valley Road was so extraordinary that the Galvins became one of the first families to be studied by the National Institute of Mental Health. Their story offers a shadow history of the science of schizophrenia, from the era of institutionalization, lobotomy, and the schizophrenogenic mother to the search for genetic markers for the disease, always amid profound disagreements about the nature of the illness itself. And unbeknownst to the Galvins, samples of their DNA informed decades of genetic research that continues today, offering paths to treatment, prediction, and even eradication of the disease for future generations.With clarity and compassion, bestselling and award-winning author Robert Kolker uncovers one family's unforgettable legacy of suffering, love, and hope.

INSTANT NEW YORK TIMES BESTSELLER • WALL STREET JOURNAL BESTSELLER • #1 GLOBE AND MAIL BESTSELLER • USA TODAY BESTSELLER You are not broken. Being a woman is not a diagnosis. Take your body back with the groundbreaking new science for women in Hormone Intelligence. Hormonal. We all know what it means when we hear it – and feel it. While hormonal shifts are natural throughout women’s lives, too many experience distressing period symptoms, struggle daily with PCOS, endometriosis, a fertility challenge, pain, low sex drive, sleep problems, acne, bloating, hot flashes, and more – all due to hormone-related problems. And too many are unable to get the answers they’re really seeking from their doctors. There is a solution. In Hormone Intelligence, Yale trained and internationally renowned women’s health expert, Dr. Aviva Romm, helps you identify the root causes of your symptoms and guides you through a 6-week proven program to achieve lifelong hormonal and gynecologic health. Using a holistic, dietary and lifestyle changing approach, Hormone Intelligence goes beyond treating symptoms to the deeper factors impacting women’s health, so you can reclaim your body, hormones, and self. Inside Hormone Intelligence, you’ll find: ·       Hormone Health 101: Understand the key components of the hormone epidemic and associated dietary and lifestyle triggers. ·       Symptoms and Root Causes Demystified: Discover what your symptoms are saying about your hormones with quizzes, checklists, trackers, and more. ·       A 6-Week Action Plan: Learn what foods you should indulge and avoid, how to repair your microbiome to support hormone health, how to identify environmental hormone disruptors, engage your body’s natural detoxification systems and reduce hidden inflammation, and the lifestyle changes that lead to happy, healthy hormones. ·       Delicious, done-for-you meal plans to take you through the entire program, including vegan options. Hormone Intelligence is an invitation to a whole new relationship with your body and hormones, the exhale you’ve been waiting for, and the first step on the road to realizing that a diagnosis does not have to be your destiny. Extended references, a complete index, and additional resources for Hormone Intelligence can be found at the author's website. 

'Ground-breaking, fascinating, important . . . we were astounded' Deliciously Ella, Delicious Ways to Feel BetterA myth-busting tour of the body's hidden foundations from a pioneering evolutionary biologistOver the past twenty years, evolutionary biologist Herman Pontzer has conducted ground-breaking studies across a range of settings, including pioneering fieldwork with Hadza hunter-gatherers in northern Tanzania.This book draws on his eye-opening research to show how, contrary to received wisdom, exercise does not increase our metabolism. Instead, we burn calories within a very narrow range: nearly 3,000 calories per day, no matter our activity level.By taking a closer look at what happens to the energy we consume, Pontzer explores the ways in which metabolism controls every aspect of our health - from fertility to immune function - and reveals the truth about the dynamic system that sustains us. Filled with facts and memorable anecdotes, Burn will change the way you think about food, exercise and life.

For readers of Atul Gawande and Paul Kalanithi, a palliative care doctor's breathtaking stories from 30 years spent caring for the dying.Modern medical technology is allowing us to live longer and fuller lives than ever before. And for the most part, that is good news. But with changes in the way we understand medicine come changes in the way we understand death. Once a familiar, peaceful, and gentle -- if sorrowful -- transition, death has come to be something from which we shield our eyes, as we prefer to fight desperately against it rather than accept its inevitability.Dr. Kathryn Mannix has studied and practiced palliative care for thirty years. In With the End in Mind , she shares beautifully crafted stories from a lifetime of caring for the dying, and makes a compelling case for the therapeutic power of approaching death not with trepidation, but with openness, clarity, and understanding.Weaving the details of her own experiences as a caregiver through stories of her patients, their families, and their distinctive lives, Dr. Mannix reacquaints us with the universal, but deeply personal, process of dying. With insightful meditations on life, death, and the space between them, With the End in Mind describes the possibility of meeting death gently, with forethought and preparation, and shows the unexpected beauty, dignity, and profound humanity of life coming to an end.

A groundbreaking mind-body protocol to heal chronic pain, backed by new research. Chronic pain is an epidemic. Fifty million Americans struggle with back pain, headaches, or some other pain that resists all treatment. Desperate pain sufferers are told again and again that there is no cure for chronic pain. Alan Gordon, a psychotherapist and the founder of the Pain Psychology Center in Los Angeles, was in grad school when he started experiencing chronic pain and it completely derailed his life. He saw multiple doctors and received many diagnoses, but none of the medical treatments helped. Frustrated with conventional pain management, he developed Pain Reprocessing Therapy (PRT), a mind-body protocol that eliminated his own chronic pain and has transformed the lives of thousands of his patients. PRT is rooted in neuroscience, which has shown that while chronic pain feels like it's coming from the body, in most cases it's generated by misfiring pain circuits in the brain. PRT is a system of psychological techniques that rewires the brain to break out of the cycle of chronic pain. The University of Colorado-Boulder recently conducted a large randomized controlled study on PRT, and the results are remarkable. By the end of the study, the majority of patients were pain-free or nearly pain-free. What's more, these dramatic changes held up over time. The Way Out brings PRT to readers. It combines accessible science with a concrete, step-by-step plan to teach sufferers how to heal their own chronic pain.

An examination of the contemporary medicalization of death and dying that calls us to acknowledge instead death's existential and emotional realities. Death is a natural, inevitable, and deeply human process, and yet Western medicine tends to view it as a medical failure. In their zeal to prevent death, physicians and hospitals often set patients and their families on a seemingly unstoppable trajectory toward medical interventions that may actually increase suffering at the end of life. This volume in the MIT Press Essential Knowledge series examines the medicalization of death and dying and proposes a different approach--one that acknowledges death's existential and emotional realities. The authors--one an academic who teaches and studies end-of-life care, and the other a physician trained in hospice and palliative care--offer an account of Western-style death and dying that is informed by both research and personal experience. They examine the medical profession's attitude toward death as a biological dysfunction that needs fixing; describe the hospice movement, as well as movements for palliative care and aid in dying, and why they failed to influence mainstream medicine; consider our reluctance to have end-of-life conversations; and investigate the commodification of medicine and the business of dying. To help patients die in accordance with their values, they say, those who care for the dying should focus less on delaying death by any means possible and more on being present with the dying on their journey.

From trauma educator and somatic guide Kimberly Ann Johnson comes a cutting-edge guide for tapping into the wisdom and resilience of the body to rewire the nervous system, heal from trauma, and live fully. In an increasingly polarized world where trauma is often publicly renegotiated, our nervous systems are on high alert. From skyrocketing rates of depression and anxiety to physical illnesses such as autoimmune diseases and digestive disorders, many women today find themselves living out of alignment with their bodies. Kimberly Johnson is a somatic practitioner, birth doula, and postpartum educator who specializes in helping women recover from all forms of trauma. In her work, she’s seen the same themes play out time and again. In a culture that prioritizes executive function and “mind over matter,” many women are suffering from deeply unresolved pain that causes mental and physical stagnation and illness. In Call of the Wild, Johnson offers an eye-opening look at this epidemic as well as an informative view of the human nervous system and how it responds to difficult events. From the “small t” traumas of getting ghosted, experiencing a fall-out with a close friend, or swerving to avoid a car accident to the “capital T” traumas of sexual assault, an upending natural disaster, or a life-threatening illness—Johnson explains how the nervous system both protects us from immediate harm and creates reverberations that ripple through a lifetime. In this practical, empowering guide, Johnson shows readers how to metabolize these nervous system responses, allowing everyone to come home to their deepest, most intuitive and whole selves. Following her supportive advice, readers will learn how to move from wholeness, tapping into the innate wisdom of their senses, soothing frayed nerves and reconnecting with their “animal selves.” While we cannot cure the painful cultural rifts inflicting our society, there is a path forward—through our bodies.