Recommendations based on "Gross Anatomy: Dispatches from the Front (and Back)"

In this paradigm-shifting book from acclaimed Harvard Medical School doctor and one of TIME magazine's 100 most influential people on earth, Dr. David Sinclair reveals that everything we think we know about ageing is wrong, and shares the surprising, scientifically-proven methods that can help readers live younger, longer. For decades, the medical community has looked to a variety of reasons for why we age, and the consensus is that no one dies of old age; they die of age-related diseases. That's because ageing is not a disease - it is inevitable.But what if everything you think you know about ageing is wrong?What if ageing is a disease? And that disease is curable.In THE EVOLUTION OF AGEING, Dr. David Sinclair, one of the world's foremost authorities on genetics and ageing, argues just that. He has dedicated his life's work to chasing more than a longer lifespan - he wants to enable people to live longer, healthier, and disease-free well into our hundreds. In this book, he reveals a bold new theory of ageing, one that pinpoints a root cause of ageing that lies in an ancient genetic survival circuit. This genetic trick - a circuit designed to halt reproduction in order to repair damage to the genome -has enabled earth's early microcosms to survive and evolve into more advanced organisms. But this same survival circuit is the reason we age: as genetic damage accumulates over our lifespans from UV rays, environmental toxins, and unhealthy diets, our genome is overwhelmed, causing gray hair, wrinkles, achy joints, heart issues, dementia, and, ultimately, death.But genes aren't our destiny; we have more control over them than we've been taught to believe. We can't change our DNA, but we can harness the power of the epigenome to realise the true potential of our genes. Drawing on his cutting-edge findings at the forefront of medical research, Dr. Sinclair will provide a scientifically-proven roadmap to reverse the genetic clock by activating our vitality genes, so we can live younger longer. Readers will discover how a few simple lifestyle changes - like intermittent fasting, avoiding too much animal protein, limiting sugar, avoiding x-rays, exercising with the right intensity, and even trying cold therapy - can activate our vitality genes. Dr. Sinclair ends the book with a look to the near future, exploring what the world might look like - and what will need to change - when we are all living well to 120 or more.Dr. Sinclair takes what we have long accepted as the limits of human potential and mortality and turns them into choices. THE EVOLUTION OF AGEING is destined to be the biggest book on genes, biology, and longevity of this decade.

Reader-friendly Cell Biology, 4th Edition, provides a concise but comprehensive foundation for students entering research or health care career paths. Award winning illustrations help readers quickly grasp general principles. The authors have thoroughly updated this popular text to provide readers with the current understanding of the principles of normal cellular function along with examples of how molecular defects predispose to human disease. Major new themes in the 4th edition include the roles of intrinsically disordered polypeptides and phase separation in cellular functions, the influence of new molecular structures on understanding mechanisms, and the impact of exciting new methods―from single cell RNA sequencing to second generation super resolution fluorescence microscopy―on advancing our understanding.Clear, readable explanations provide a concise story about how cells function at the molecular level.An intuitive chapter flow starts with genome organization, gene expression, and RNA processing as a foundation for understanding every aspect of cellular function and physiology.Brings cellular biology to life for students interested in medical science by explaining how mutations in genes can compromise virtually every cellular system and predispose to human disease. Knowledge of cell biology has led to new treatments for cancer, heart failure, cystic fibrosis, and many other diseases.Unique illustrations with realistic proportions and relationships explain every cellular process including the assembly of SARS CoV-2, the structures attaching mitotic chromosomes to microtubules, the mechanism of DNA replication and how pumps, carriers and channels orchestrate physiological processes from synaptic transmission to cellular volume regulation.Covers exciting breakthroughs such as SMC motor proteins actively organizing chromosomal DNA, TOR kinases regulating metabolism, new types of immunotherapy for cancer treatment, mechanisms regulating fast axonal transport and their relation to neurodegenerative diseases, how completion of DNA replication sets the time for cells to enter mitosis, how a cascade of signals specifies the site of cell division, and newly understood pathways of normal and pathological cell death.Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

A riveting medical mystery about a young woman’s quest to uncover the truth about her likely fatal genetic disorder that opens a window onto the exploding field of genomic medicine When Joselin Linder was in her twenties her legs suddenly started to swell. After years of misdiagnoses, doctors discovered a deadly blockage in her liver. Struggling to find  an explanation for her unusual condition, Joselin compared the medical chart of her father—who had died from a mysterious disease, ten years prior—with that of an uncle who had died under similarly strange circumstances. Delving further into the past, she discovered that her great-grandmother had displayed symptoms similar to hers before her death. Clearly, this was more than a fluke. Setting out to build a more complete picture of the illness that haunted her family, Joselin approached Dr. Christine Seidman, the head of a group of world-class genetic researchers at Harvard Medical School, for help. Dr. Seidman had been working on her family’s case for twenty years and had finally confirmed that fourteen of Joselin’s relatives carried something called a private mutation—meaning that they were the first known people to experience the baffling symptoms of a brand new genetic mutation. Here, Joselin tells the story of their gene: the lives it claimed and the future of genomic medicine with the potential to save those that remain.  Digging into family records and medical history, conducting interviews with relatives and friends, and reflecting on her own experiences with the Harvard doctor, Joselin pieces together the lineage of this deadly gene to write a gripping and unforgettable exploration of family, history, and love. A compelling chronicle of survival and perseverance, The Family Gene is an important story of a young woman reckoning with her father’s death, her own mortality, and her ethical obligations to herself and those closest to her.

#1 NEW YORK TIMES BESTSELLER • OPRAH’S BOOK CLUB PICK • ONE OF GQ's TOP 50 BOOKS OF LITERARY JOURNALISM IN THE 21st CENTURY • The heartrending story of a midcentury American family with twelve children, six of them diagnosed with schizophrenia, that became science's great hope in the quest to understand the disease."Reads like a medical detective journey and sheds light on a topic so many of us face: mental illness." —Oprah WinfreyDon and Mimi Galvin seemed to be living the American dream. After World War II, Don's work with the Air Force brought them to Colorado, where their twelve children perfectly spanned the baby boom: the oldest born in 1945, the youngest in 1965. In those years, there was an established script for a family like the Galvins--aspiration, hard work, upward mobility, domestic harmony--and they worked hard to play their parts. But behind the scenes was a different story: psychological breakdown, sudden shocking violence, hidden abuse. By the mid-1970s, six of the ten Galvin boys, one after another, were diagnosed as schizophrenic. How could all this happen to one family?What took place inside the house on Hidden Valley Road was so extraordinary that the Galvins became one of the first families to be studied by the National Institute of Mental Health. Their story offers a shadow history of the science of schizophrenia, from the era of institutionalization, lobotomy, and the schizophrenogenic mother to the search for genetic markers for the disease, always amid profound disagreements about the nature of the illness itself. And unbeknownst to the Galvins, samples of their DNA informed decades of genetic research that continues today, offering paths to treatment, prediction, and even eradication of the disease for future generations.With clarity and compassion, bestselling and award-winning author Robert Kolker uncovers one family's unforgettable legacy of suffering, love, and hope.

INSTANT NEW YORK TIMES BESTSELLER • WALL STREET JOURNAL BESTSELLER • #1 GLOBE AND MAIL BESTSELLER • USA TODAY BESTSELLER You are not broken. Being a woman is not a diagnosis. Take your body back with the groundbreaking new science for women in Hormone Intelligence. Hormonal. We all know what it means when we hear it – and feel it. While hormonal shifts are natural throughout women’s lives, too many experience distressing period symptoms, struggle daily with PCOS, endometriosis, a fertility challenge, pain, low sex drive, sleep problems, acne, bloating, hot flashes, and more – all due to hormone-related problems. And too many are unable to get the answers they’re really seeking from their doctors. There is a solution. In Hormone Intelligence, Yale trained and internationally renowned women’s health expert, Dr. Aviva Romm, helps you identify the root causes of your symptoms and guides you through a 6-week proven program to achieve lifelong hormonal and gynecologic health. Using a holistic, dietary and lifestyle changing approach, Hormone Intelligence goes beyond treating symptoms to the deeper factors impacting women’s health, so you can reclaim your body, hormones, and self. Inside Hormone Intelligence, you’ll find: ·       Hormone Health 101: Understand the key components of the hormone epidemic and associated dietary and lifestyle triggers. ·       Symptoms and Root Causes Demystified: Discover what your symptoms are saying about your hormones with quizzes, checklists, trackers, and more. ·       A 6-Week Action Plan: Learn what foods you should indulge and avoid, how to repair your microbiome to support hormone health, how to identify environmental hormone disruptors, engage your body’s natural detoxification systems and reduce hidden inflammation, and the lifestyle changes that lead to happy, healthy hormones. ·       Delicious, done-for-you meal plans to take you through the entire program, including vegan options. Hormone Intelligence is an invitation to a whole new relationship with your body and hormones, the exhale you’ve been waiting for, and the first step on the road to realizing that a diagnosis does not have to be your destiny. Extended references, a complete index, and additional resources for Hormone Intelligence can be found at the author's website. 

"While we accept that stress or anxiety can damage our health, the idea of 'healing thoughts' was long ago hijacked by New Age gurus and spiritual healers. Recently, however, serious scientists ... have been uncovering evidence that our thoughts, emotions, and beliefs can ease pain, heal wounds, fend off infection and heart disease, even slow the progression of AIDS and some cancers. In [this book], ... Marchant travels the world to meet the physicians, patients, and researchers on the cutting edge of this new world of medicine. We learn how meditation protects against depression and dementia, how social connections increase life expectancy, and how patients who feel cared for recover from surgery faster"--

“Nicole Jardim walks the talk, and I am confident that Fix Your Period will help ignite the hormone balance you are seeking and restore your vitality.” --Sara Gottfried, MD, New York Times bestselling author of The Hormone CureA life-changing step-by-step natural protocol to ignite lasting hormone balance and improve everything from PMS, period pain, and heavy periods to irregular cycles and missing periods, from Nicole Jardim, certified women’s health coach and co-host of the podcast The Period Party.For most women, getting their period sucks. Bloating. Cramps. Acne. Aches. Moodiness. Messiness. No wonder we call it The Curse! For many, it’s not just an inconvenience—it’s a colossal life disruption, forcing them to miss work, school, appointments, or dates.We’ve been encouraged to medicate away common period problems with birth control and ibuprofen, and just survive the mood swings as best we can. But as Nicole Jardim explains, periods aren’t a nuisance, they’re information. When you learn to decode your period (or lack thereof), you’ll be able to recognize the underlying hormone imbalances causing your period problems and know how to fix them naturally with Jardim’s proven six-week protocol to resolve even the most challenging hormone imbalances and menstruation issues.Joining the ranks of books by Jolene Brighten, Sara Gottfried, and Aviva Romm, Nicole Jardim’s Fix Your Period is essential for women plagued by PMS, irregular, painful, or heavy periods, PCOS, Endometriosis, or fibroids—and for anyone who wants to take charge of her hormonal health—and regain control of her life—naturally.

In this landmark book of popular science, Daniel E. Lieberman—chair of the department of human evolutionary biology at Harvard University and a leader in the field—gives us a lucid and engaging account of how the human body evolved over millions of years, even as it shows how the increasing disparity between the jumble of adaptations in our Stone Age bodies and advancements in the modern world is occasioning this paradox: greater longevity but increased chronic disease.   The Story of the Human Body brilliantly illuminates as never before the major transformations that contributed key adaptations to the body: the rise of bipedalism; the shift to a non-fruit-based diet; the advent of hunting and gathering, leading to our superlative endurance athleticism; the development of a very large brain; and the incipience of cultural proficiencies. Lieberman also elucidates how cultural evolution differs from biological evolution, and how our bodies were further transformed during the Agricultural and Industrial Revolutions.   While these ongoing changes have brought about many benefits, they have also created conditions to which our bodies are not entirely adapted, Lieberman argues, resulting in the growing incidence of obesity and new but avoidable diseases, such as type 2 diabetes. Lieberman proposes that many of these chronic illnesses persist and in some cases are intensifying because of “dysevolution,” a pernicious dynamic whereby only the symptoms rather than the causes of these maladies are treated. And finally—provocatively—he advocates the use of evolutionary information to help nudge, push, and sometimes even compel us to create a more salubrious environment. (With charts and line drawings throughout.)

How does medical science advance? Popular historians would have us believe that a few heroic individuals, possessing superhuman talents, lead an unselfish quest to better the human condition. But as renowned Yale surgeon and medical historian Sherwin B. Nuland shows in this brilliant collection of linked life portraits, the theory bears little resemblance to the truth.Through the centuries, the men and women Who have shaped the world of medicine have been not only very human people but also very much the products of their own times and places. Presenting compelling studies of great medical innovators and pioneers, Doctors gives us the extraordinary story of the development of modern medicine -- told through the lives of the physician-scientists whose deeds and determination paved the way. Ranging from the legendary Father of Medicine, Hippocrates, to Andreas Vesalius, whose Renaissance masterwork on anatomy offered invaluable new insight into the human body, to Helen Taussig, founder of pediatric cardiology and co-inventor of the original "blue baby" operation, here is a volume filled with the spirit of ideas and the thrill of discovery. Says The New York Times, "Doctors can be warmly recommended. Dr. Nuland succeeds in bringing his subjects vividly to life, and he leaves you with a much better understanding of what they achieved."From the Trade Paperback edition.

Introduction: "He is still out there"--What came before zero? -- The cluster study -- "Humanizing this disease" -- Giving a face to the epidemic -- Ghosts and blood -- Locating Gaétan Dugas's views -- Epilogue: zero hour-making histories of the North American AIDS epidemic