Recommendations based on "Being Mortal Illness, Medicine and what Matters in the End"

It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan?In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.”This book takes us to the frontlines of research many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it.

In this paradigm-shifting book from acclaimed Harvard Medical School doctor and one of TIME magazine's 100 most influential people on earth, Dr. David Sinclair reveals that everything we think we know about ageing is wrong, and shares the surprising, scientifically-proven methods that can help readers live younger, longer. For decades, the medical community has looked to a variety of reasons for why we age, and the consensus is that no one dies of old age; they die of age-related diseases. That's because ageing is not a disease - it is inevitable.But what if everything you think you know about ageing is wrong?What if ageing is a disease? And that disease is curable.In THE EVOLUTION OF AGEING, Dr. David Sinclair, one of the world's foremost authorities on genetics and ageing, argues just that. He has dedicated his life's work to chasing more than a longer lifespan - he wants to enable people to live longer, healthier, and disease-free well into our hundreds. In this book, he reveals a bold new theory of ageing, one that pinpoints a root cause of ageing that lies in an ancient genetic survival circuit. This genetic trick - a circuit designed to halt reproduction in order to repair damage to the genome -has enabled earth's early microcosms to survive and evolve into more advanced organisms. But this same survival circuit is the reason we age: as genetic damage accumulates over our lifespans from UV rays, environmental toxins, and unhealthy diets, our genome is overwhelmed, causing gray hair, wrinkles, achy joints, heart issues, dementia, and, ultimately, death.But genes aren't our destiny; we have more control over them than we've been taught to believe. We can't change our DNA, but we can harness the power of the epigenome to realise the true potential of our genes. Drawing on his cutting-edge findings at the forefront of medical research, Dr. Sinclair will provide a scientifically-proven roadmap to reverse the genetic clock by activating our vitality genes, so we can live younger longer. Readers will discover how a few simple lifestyle changes - like intermittent fasting, avoiding too much animal protein, limiting sugar, avoiding x-rays, exercising with the right intensity, and even trying cold therapy - can activate our vitality genes. Dr. Sinclair ends the book with a look to the near future, exploring what the world might look like - and what will need to change - when we are all living well to 120 or more.Dr. Sinclair takes what we have long accepted as the limits of human potential and mortality and turns them into choices. THE EVOLUTION OF AGEING is destined to be the biggest book on genes, biology, and longevity of this decade.

If it weren't for mitochondria, scientists argue, we'd all still be single-celled bacteria. Indeed, these tiny structures inside our cells are important beyond imagining. Without mitochondria, we would have no cell suicide, no sculpting of embryonic shape, no sexes, no menopause, no aging.In this fascinating and thought-provoking book, Nick Lane brings together the latest research in this exciting field to show how our growing insight into mitochondria has shed light on how complex life evolved, why sex arose (why don't we just bud?), and why we age and die. These findings are of fundamental importance, both in understanding life on Earth, but also in controlling our own illnesses, and delaying our degeneration and death. Readers learn that two billion years ago, mitochondria were probably bacteria living independent lives and that their capture within larger cells was a turning point in the evolution of life, enabling the development of complex organisms. Lane describes how mitochondria have their own DNA and that its genes mutate much faster than those in the nucleus. This high mutation rate lies behind our aging and certain congenital diseases. The latest research suggests that mitochondria play a key role in degenerative diseases such as cancer. We also discover that mitochondrial DNA is passed down almost exclusively via the female line. That's why it has been used by some researchers to trace human ancestry daughter-to-mother, to "Mitochondrial Eve," giving us vital information about our evolutionary history.Written by Nick Lane, a rising star in popular science, Power, Sex, Suicide is the first book for general readers on the nature and function of these tiny, yet fascinating structures.

Meet the ninety year old doctor, who, with the aid of a few simple exercises, is still practising medicine. His is just one of the incredible stories brain expert Norman Doidge tells as he reveals our brain's remarkable ability to repair itself through the power of positive thought. In The Brain That Changes Itself Doidge introduces us to the fascinating stories at the cutting edge of the brain science and the emerging discipline of 'neuroplasticity' . We meet the stroke victim who unable to feed or dress himself learned to move and talk again, the woman with a rare brain condition that left her feeling as though she was perpetually falling but who through a series of exercises rewired her brain to overcome this and the maverick scientists over turning centuries of assumptions about the brain and it's capacity for renewal. Doidge shows how their incredible work is helping the blind to see, the deaf to hear and causing Nobel laureates to rethink our model of the brain.

'Ground-breaking, fascinating, important . . . we were astounded' Deliciously Ella, Delicious Ways to Feel BetterA myth-busting tour of the body's hidden foundations from a pioneering evolutionary biologistOver the past twenty years, evolutionary biologist Herman Pontzer has conducted ground-breaking studies across a range of settings, including pioneering fieldwork with Hadza hunter-gatherers in northern Tanzania.This book draws on his eye-opening research to show how, contrary to received wisdom, exercise does not increase our metabolism. Instead, we burn calories within a very narrow range: nearly 3,000 calories per day, no matter our activity level.By taking a closer look at what happens to the energy we consume, Pontzer explores the ways in which metabolism controls every aspect of our health - from fertility to immune function - and reveals the truth about the dynamic system that sustains us. Filled with facts and memorable anecdotes, Burn will change the way you think about food, exercise and life.

What is it like to be a brain surgeon? How does it feel to hold someone's life in your hands, to cut into the stuff that creates thought, feeling, and reason? How do you live with the consequences of performing a potentially lifesaving operation when it all goes wrong?In neurosurgery, more than in any other branch of medicine, the doctor's oath to "do no harm" holds a bitter irony. Operations on the brain carry grave risks. Every day, leading neurosurgeon Henry Marsh must make agonizing decisions, often in the face of great urgency and uncertainty.If you believe that brain surgery is a precise and exquisite craft, practiced by calm and detached doctors, this gripping, brutally honest account will make you think again. With astonishing compassion and candor, Marsh reveals the fierce joy of operating, the profoundly moving triumphs, the harrowing disasters, the haunting regrets, and the moments of black humor that characterize a brain surgeon's life.Do No Harm provides unforgettable insight into the countless human dramas that take place in a busy modern hospital. Above all, it is a lesson in the need for hope when faced with life's most difficult decisions.

From a leading neurologist, neuroscientist and practitioner of Ayurvedic medicine, comes a rigorous scientific investigation of the healing power of sound, showing readers how they can use it to improve their mental and physical wellbeing.Why does a baby’s cry instantaneously flood a mother’s body with a myriad of stress hormones? How can a song on the radio stir up powerful emotions, from joy to anger, regret to desire? Why does sound itself evoke such primal and deeply felt emotions?A vibration that travels through air, water and solids, sound is produced by all matter, and is a fundamental part of every species’ survival. But there is a hidden power within sound that has only just begun to be investigated. Sound Medicine takes readers on a journey through the structure of the mouth, ears, and brain to understand how sound is translated from acoustic vibrations into meaningful neurological impulses. Renowned neurologist and Ayurvedic expert Dr. Kulreet Chaudhary explains how different types of sound impact the human body and brain uniquely, and explores the physiological effects of sound vibration, from altering mood to healing disease.Blending ancient wisdom with modern science, Dr. Chaudhary traces the history of sound therapy and the use of specific mantras from previously unknown texts—traced back to the Siddhas, a group of enlightened yogis who created a healing tradition that served as the precursor to Ayurvedic medicine—to explain the therapeutic application of sounds for a wide range of conditions. Sound Medicine offers practical, step-by-step lessons for using music and mantras, whether you’re a beginner or searching for a more advanced practice, to improve your health in body, mind, and spirit.

The range of environments in which people can survive is extensive, yet most of the natural world cannot support human life. The Biology of Human Survival identifies the key determinants of life or death in extreme environments from a physiologist's perspective, integrating modern concepts of stress, tolerance, and adaptation into explanations of life under Nature's most austere conditions. The book examines how individuals survive when faced with extremes of immersion, heat, cold or altitude, emphasizing the body's recognition of stress and the brain's role in optimizing physiological function in order to provide time to escape or to adapt. In illustrating how human biology adapts to extremes, the book also explains how we learn to cope by blending behavior and biology, first by trial and error, then by rigorous scientific observation, and finally by technological innovation. The book describes life-support technology and how it enables humans to enter once unendurable realm, from the depths of the ocean to the upper reaches of the atmosphere and beyond. Finally, it explores the role that advanced technology might play in special environments of the future, such as long journeys into space.

While it may seem that debates over euthanasia began with Jack Kervorkian, the practice of mercy killing extends back to Ancient Greece and beyond. In America, the debate has raged for well over a century. Now, in A Merciful End, Ian Dowbiggin offers the first full-scale historical account of one of the most controversial reform movements in America. Drawing on unprecedented access to the archives of the Euthanasia Society of America, interviews with important figures in the movement today, and flashpoint cases such as the tragic fate of Karen Ann Quinlan, Dowbiggin tells the dramatic story of the men and women who struggled throughout the twentieth century to change the nation's attitude--and its laws--regarding mercy killing. In tracing the history of the euthanasia movement, he documents its intersection with other progressive social causes: women's suffrage, birth control, abortion rights, as well as its uneasy pre-WWII alliance with eugenics. Such links brought euthanasia activists into fierce conflict with Judeo-Christian institutions who worried that "the right to die" might become a "duty to die." Indeed, Dowbiggin argues that by joining a sometimes overzealous quest to maximize human freedom with a desire to "improve" society, the euthanasia movement has been dogged by the fear that mercy killing could be extended to persons with disabilities, handicapped newborns, unconscious geriatric patients, lifelong criminals, and even the poor. Justified or not, such fears have stalled the movement, as more and more Americans now prefer better end-of-life care than wholesale changes in euthanasia laws. For anyone trying to decide whether euthanasia offers a humane alternative to prolonged suffering or violates the "sanctity of life," A Merciful End provides fascinating and much-needed historical context.

**THE SUNDAY TIMES BESTSELLER**'You're amazing I could talk to you (Rahul) all day' Chris Evans'This is a gripping new book' The TimesWorld-leading neuroscientist and neurosurgeon Dr Rahul Jandial draws on his years of work with patients suffering from the most extreme cases of brain damage, disorders and illnesses to reveal what they can tell us about the science of the mind.From a languages teacher who has to choose whether to lose her ability to speak Spanish or English after brain surgery, to a former TV exec, now homeless, who discovers that his life-altering despondency is the result of a tumour, to a fainting teen who learns that deep breathing can mean the difference between life or death, these stories uncover the secret workings of the brain.Blending cutting-edge research and beautiful storytelling, Life Lessons from a Brain Surgeon is a vital resource on the best ways to boost your memory, control stress and emotions, minimize pain, unleash your creativity, raise smart kids and reduce the risk of Alzheimer's. This is a deeply practical and readable book, which will take you on an expedition through the anatomy of the most fascinating - and mysterious - of organs.