Empfehlungen basierend auf "The Premonition: A Pandemic Story"

It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan?In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.”This book takes us to the frontlines of research many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it.

If it weren't for mitochondria, scientists argue, we'd all still be single-celled bacteria. Indeed, these tiny structures inside our cells are important beyond imagining. Without mitochondria, we would have no cell suicide, no sculpting of embryonic shape, no sexes, no menopause, no aging.In this fascinating and thought-provoking book, Nick Lane brings together the latest research in this exciting field to show how our growing insight into mitochondria has shed light on how complex life evolved, why sex arose (why don't we just bud?), and why we age and die. These findings are of fundamental importance, both in understanding life on Earth, but also in controlling our own illnesses, and delaying our degeneration and death. Readers learn that two billion years ago, mitochondria were probably bacteria living independent lives and that their capture within larger cells was a turning point in the evolution of life, enabling the development of complex organisms. Lane describes how mitochondria have their own DNA and that its genes mutate much faster than those in the nucleus. This high mutation rate lies behind our aging and certain congenital diseases. The latest research suggests that mitochondria play a key role in degenerative diseases such as cancer. We also discover that mitochondrial DNA is passed down almost exclusively via the female line. That's why it has been used by some researchers to trace human ancestry daughter-to-mother, to "Mitochondrial Eve," giving us vital information about our evolutionary history.Written by Nick Lane, a rising star in popular science, Power, Sex, Suicide is the first book for general readers on the nature and function of these tiny, yet fascinating structures.

Journalist Beth Macy's definitive account of America's opioid epidemic "masterfully interlaces stories of communities in crisis with dark histories of corporate greed and regulatory indifference" (New York Times) -- from the boardroom to the courtroom and into the living rooms of Americans.In this extraordinary work, Beth Macy takes us into the epicenter of a national drama that has unfolded over two decades. From the labs and marketing departments of big pharma to local doctor's offices; wealthy suburbs to distressed small communities in Central Appalachia; from distant cities to once-idyllic farm towns; the spread of opioid addiction follows a tortuous trajectory that illustrates how this crisis has persisted for so long and become so firmly entrenched.Beginning with a single dealer who lands in a small Virginia town and sets about turning high school football stars into heroin overdose statistics, Macy sets out to answer a grieving mother's question-why her only son died-and comes away with a gripping, unputdownable story of greed and need. From the introduction of OxyContin in 1996, Macy investigates the powerful forces that led America's doctors and patients to embrace a medical culture where overtreatment with painkillers became the norm. In some of the same communities featured in her bestselling book Factory Man, the unemployed use painkillers both to numb the pain of joblessness and pay their bills, while privileged teens trade pills in cul-de-sacs, and even high school standouts fall prey to prostitution, jail, and death.Through unsparing, compelling, and unforgettably humane portraits of families and first responders determined to ameliorate this epidemic, each facet of the crisis comes into focus. In these politically fragmented times, Beth Macy shows that one thing uniting Americans across geographic, partisan, and class lines is opioid drug abuse. But even in the midst of twin crises in drug abuse and healthcare, Macy finds reason to hope and ample signs of the spirit and tenacity that are helping the countless ordinary people ensnared by addiction build a better future for themselves, their families, and their communities."An impressive feat of journalism, monumental in scope and urgent in its implications." -- Jennifer Latson, The Boston Globe

What is it like to be a brain surgeon? How does it feel to hold someone's life in your hands, to cut into the stuff that creates thought, feeling, and reason? How do you live with the consequences of performing a potentially lifesaving operation when it all goes wrong?In neurosurgery, more than in any other branch of medicine, the doctor's oath to "do no harm" holds a bitter irony. Operations on the brain carry grave risks. Every day, leading neurosurgeon Henry Marsh must make agonizing decisions, often in the face of great urgency and uncertainty.If you believe that brain surgery is a precise and exquisite craft, practiced by calm and detached doctors, this gripping, brutally honest account will make you think again. With astonishing compassion and candor, Marsh reveals the fierce joy of operating, the profoundly moving triumphs, the harrowing disasters, the haunting regrets, and the moments of black humor that characterize a brain surgeon's life.Do No Harm provides unforgettable insight into the countless human dramas that take place in a busy modern hospital. Above all, it is a lesson in the need for hope when faced with life's most difficult decisions.

High Price is the harrowing and inspiring memoir of neuroscientist Carl Hart, a leading researcher in the field of drug addiction, who grew up in one of Miami’s toughest neighborhoods and, determined to make a difference as an adult, tirelessly applies his scientific training to help save real lives. WINNER OF THE PEN/E. O. WILSON LITERARY SCIENCE WRITING AWARD Young Carl didn't see the value of school, studying just enough to keep him on the basketball team. Today, he is a cutting-edge neuroscientist—Columbia University’s first tenured African American professor in the sciences—whose landmark, controversial research is redefining our understanding of addiction. In this provocative and eye-opening memoir, Dr. Carl Hart recalls his journey of self-discovery, how he escaped a life of crime and drugs and avoided becoming one of the crack addicts he now studies. Interweaving past and present, Hart goes beyond the hype as he examines the relationship between drugs and pleasure, choice, and motivation, both in the brain and in society. His findings shed new light on common ideas about race, poverty, and drugs, and explain why current policies are failing.

The United States, we are told, is facing an obesity epidemic-a "battle of the bulge" of not just national, but global proportions-that requires drastic and immediate action. Experts in the media, medical science, and government alike are scrambling to find answers. What or who is responsible for this fat crisis, and what can we do to stop it?Abigail Saguy argues that these fraught and frantic debates obscure a more important question: How has fatness come to be understood as a public health crisis at all? Why, she asks, has the view of "fat" as a problem-a symptom of immorality, a medical pathology, a public health epidemic-come to dominate more positive framings of weight-as consistent with health, beauty, or a legitimate rights claim-in public discourse? Why are heavy individuals singled out for blame? And what are the consequences of understanding weight in these ways?What's Wrong with Fat? presents each of the various ways in which fat is understood in America today, examining the implications of understanding fatness as a health risk, disease, and epidemic, and revealing why we've come to understand the issue in these terms, despite considerable scientific uncertainty and debate. Saguy shows how debates over the relationship between body size and health risk take place within a larger, though often invisible, contest over whether we should understand fatness as obesity at all. Moreover, she reveals that public discussions of the "obesity crisis" do more harm than good, leading to bullying, weight-based discrimination, and misdiagnoses.Showing that the medical framing of fat is literally making us sick, What's Wrong with Fat? provides a crucial corrective to our society's misplaced obsession with weight.

Guardian columnist Dr Ben Goldacre takes us on a hilarious, invigorating and informative journey through the bad science we're fed by the worst of the hacks and the quacks! When Dr Ben Goldacre saw someone on daytime TV dipping her feet in an 'Aqua Detox' footbath, releasing her toxins into the water and turning it brown, he thought he'd try the same at home. 'Like some kind of Johnny Ball cum Witchfinder General', using his girlfriend's Barbie doll, he gently passed an electrical current through the warm salt water. It turned brown. In his words: 'before my very eyes, the world's first Detox Barbie was sat, with her feet in a pool of brown sludge, purged of a weekend's immorality.' Dr Ben Goldacre is the author of the 'Bad Science' column in the Guardian and his book is about all the 'bad science' we are constantly bombarded with in the media and in advertising. At a time when science is used to prove everything and nothing, everyone has their own 'bad science' moments -- from the useless pie-chart on the back of cereal packets to the use of the word 'visibly' in cosmetics ads.This book will help people to quantify their instincts -- that a lot of the so-called 'science' which appears in the media and in advertising is just wrong or misleading. Satirical and amusing -- and unafraid to expose the ridiculous -- it provides the reader with the facts they need to differentiate the good from the bad. Full of spleen, this is a hilarious, invigorating and informative journey through the world of 'bad science'.

It lurks in the corner of our imagination, almost beyond our ability to see it: the possibility that a tear in the fabric of life could open up without warning, upending a house, a skyscraper, or a civilization.Today, nine out of ten Americans live in places at significant risk of earthquakes, hurricanes, tornadoes, terrorism, or other disasters. Tomorrow, some of us will have to make split-second choices to save ourselves and our families. How will we react? What will it feel like? Will we be heroes or victims? Will our upbringing, our gender, our personality–anything we’ve ever learned, thought, or dreamed of–ultimately matter?Amanda Ripley, an award-winning journalist for Time magazine who has covered some of the most devastating disasters of our age, set out to discover what lies beyond fear and speculation. In this magnificent work of investigative journalism, Ripley retraces the human response to some of history’s epic disasters, from the explosion of the Mont Blanc munitions ship in 1917–one of the biggest explosions before the invention of the atomic bomb–to a plane crash in England in 1985 that mystified investigators for years, to the journeys of the 15,000 people who found their way out of the World Trade Center on September 11, 2001. Then, to understand the science behind the stories, Ripley turns to leading brain scientists, trauma psychologists, and other disaster experts, formal and informal, from a Holocaust survivor who studies heroism to a master gunfighter who learned to overcome the effects of extreme fear.Finally, Ripley steps into the dark corners of her own imagination, having her brain examined by military researchers and experiencing through realistic simulations what it might be like to survive a plane crash into the ocean or to escape a raging fire.Ripley comes back with precious wisdom about the surprising humanity of crowds, the elegance of the brain’s fear circuits, and the stunning inadequacy of many of our evolutionary responses. Most unexpectedly, she discovers the brain’s ability to do much, much better, with just a little help.The Unthinkable escorts us into the bleakest regions of our nightmares, flicks on a flashlight, and takes a steady look around. Then it leads us home, smarter and stronger than we were before.

Here’s the most clinically oriented critical care text focusing on the adult patient. In full-color and superbly illustrated with clinical photographs, imaging studies, and management algorithms, and with a broad multidisciplinary focus, this text will help you enhance your skills at any level of training.Stands alone as a clinically oriented comprehensive reference. Completely updated and authorship expanded to reflect the evolution in critical care practice. In color for the first time, with new color schematics and treatment algorithms for greater ease of reference. Utilizes key points lists at the end of chapter, to help you make decisions rapidly and easily. Delivers key references that list other useful resources for information.Learn from the best ICU specialists worldwide with contributions from an increased number of international authorities. Effectively manage common complications in the ICU with updated coverage of severe sepsis, septic shock, surgical infections, neurogenic and anaphylactic shock, severe heart failure, acute coronary syndromes, and Acute Respiratory Distress Syndrome. Access the complete contents online at Expert Consult, along with an image bank and instructional videos!

In This Accessible And Groundbreaking Book -- Filled With The Moving Stories Of Real People -- Medical Doctor And Bestselling Author Of Scattered Minds, Gabor Maté, Shows That Emotion And Psychological Stress Play A Powerful Role In The Onset Of Chronic Illness. Western Medicine Achieves Spectacular Triumphs When Dealing With Acute Conditions Such As Fractured Bones Or Life-threatening Infections. It Is Less Successful Against Ailments Not Susceptible To The Quick Ministrations Of Scalpel, Antibiotic Or Miracle Drug. Trained To Consider Mind And Body Separately, Physicians Are Often Helpless In Arresting The Advance Of Most Of The Chronic Diseases, Such As Breast Cancer, Rheumatoid Arthritis, Crohn’s Disease, Multiple Sclerosis, Fibromyalgia, And Even Alzheimer’s Disease. Gabor Maté Has Found That In All Of These Chronic Conditions, There Is A Common Thread: People Afflicted By These Diseases Have Led Lives Of Excessive Stress, Often Invisible To The Individuals Themselves. From An Early Age, Many Of Us Develop A Psychological Coping Style That Keeps Us Out Of Touch With The Signs Of Stress. So-called Negative Emotions, Particularly Anger, Are Suppressed. Dr. Maté Writes With Great Conviction That Knowledge Of How Stress And Disease Are Connected Is Essential To Prevent Illness In The First Place, Or To Facilitate Healing. When The Body Says No Is An Impressive Contribution To Current Research On The Physiological Connection Between Life’s Stresses And Emotions And The Body Systems Governing Nerves, Immune Apparatus And Hormones. With Great Compassion And Erudition, Gabor Maté Demystifies Medical Science And, As He Did In Scattered Minds, Invites Us All To Be Our Own Health Advocates. Excerpt From When The Body Says No “only An Intellectual Luddite Would Deny The Enormous Benefits That Have Accrued To Humankind From The Scrupulous Application Of Scientific Methods. But Not All Aspects Of Illness Can Be Reduced To Facts Verified By Double-blind Studies And By The Strictest Scientific Techniques. We Confine Ourselves To A Narrow Realm Indeed If We Exclude From Accepted Knowledge The Contributions Of Human Experience And Insight. . . . “in 1892 William Osler, One Of The Greatest Physicians Of All Time, Suspected Rheumatoid Arthritis To Be A Stress-related Disorder. Today Rheumatology All But Ignores That Wisdom, Despite The Supporting Scientific Evidence That Has Accumulated In The 110 Years Since Osler First Published His Text. That Is Where The Narrow Scientific Approach Has Brought The Practice Of Medicine. Elevating Modern Science To Be The Final Arbiter Of Our Sufferings, We Have Been Too Eager To Discard The Insights Of Previous Ages.” From The Hardcover Edition.