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In this paradigm-shifting book from acclaimed Harvard Medical School doctor and one of TIME magazine's 100 most influential people on earth, Dr. David Sinclair reveals that everything we think we know about ageing is wrong, and shares the surprising, scientifically-proven methods that can help readers live younger, longer. For decades, the medical community has looked to a variety of reasons for why we age, and the consensus is that no one dies of old age; they die of age-related diseases. That's because ageing is not a disease - it is inevitable.But what if everything you think you know about ageing is wrong?What if ageing is a disease? And that disease is curable.In THE EVOLUTION OF AGEING, Dr. David Sinclair, one of the world's foremost authorities on genetics and ageing, argues just that. He has dedicated his life's work to chasing more than a longer lifespan - he wants to enable people to live longer, healthier, and disease-free well into our hundreds. In this book, he reveals a bold new theory of ageing, one that pinpoints a root cause of ageing that lies in an ancient genetic survival circuit. This genetic trick - a circuit designed to halt reproduction in order to repair damage to the genome -has enabled earth's early microcosms to survive and evolve into more advanced organisms. But this same survival circuit is the reason we age: as genetic damage accumulates over our lifespans from UV rays, environmental toxins, and unhealthy diets, our genome is overwhelmed, causing gray hair, wrinkles, achy joints, heart issues, dementia, and, ultimately, death.But genes aren't our destiny; we have more control over them than we've been taught to believe. We can't change our DNA, but we can harness the power of the epigenome to realise the true potential of our genes. Drawing on his cutting-edge findings at the forefront of medical research, Dr. Sinclair will provide a scientifically-proven roadmap to reverse the genetic clock by activating our vitality genes, so we can live younger longer. Readers will discover how a few simple lifestyle changes - like intermittent fasting, avoiding too much animal protein, limiting sugar, avoiding x-rays, exercising with the right intensity, and even trying cold therapy - can activate our vitality genes. Dr. Sinclair ends the book with a look to the near future, exploring what the world might look like - and what will need to change - when we are all living well to 120 or more.Dr. Sinclair takes what we have long accepted as the limits of human potential and mortality and turns them into choices. THE EVOLUTION OF AGEING is destined to be the biggest book on genes, biology, and longevity of this decade.

In this landmark book of popular science, Daniel E. Lieberman—chair of the department of human evolutionary biology at Harvard University and a leader in the field—gives us a lucid and engaging account of how the human body evolved over millions of years, even as it shows how the increasing disparity between the jumble of adaptations in our Stone Age bodies and advancements in the modern world is occasioning this paradox: greater longevity but increased chronic disease.   The Story of the Human Body brilliantly illuminates as never before the major transformations that contributed key adaptations to the body: the rise of bipedalism; the shift to a non-fruit-based diet; the advent of hunting and gathering, leading to our superlative endurance athleticism; the development of a very large brain; and the incipience of cultural proficiencies. Lieberman also elucidates how cultural evolution differs from biological evolution, and how our bodies were further transformed during the Agricultural and Industrial Revolutions.   While these ongoing changes have brought about many benefits, they have also created conditions to which our bodies are not entirely adapted, Lieberman argues, resulting in the growing incidence of obesity and new but avoidable diseases, such as type 2 diabetes. Lieberman proposes that many of these chronic illnesses persist and in some cases are intensifying because of “dysevolution,” a pernicious dynamic whereby only the symptoms rather than the causes of these maladies are treated. And finally—provocatively—he advocates the use of evolutionary information to help nudge, push, and sometimes even compel us to create a more salubrious environment. (With charts and line drawings throughout.)

In the US edition of this international bestseller, Adam Kay channels Henry Marsh and David Sedaris to tell us the "darkly funny" (The New Yorker) -- and sometimes horrifying -- truth about life and work in a hospital. Welcome to 97-hour weeks. Welcome to life and death decisions. Welcome to a constant tsunami of bodily fluids. Welcome to earning less than the hospital parking meter. Wave goodbye to your friends and relationships. Welcome to the life of a first-year doctor. Scribbled in secret after endless days, sleepless nights and missed weekends, comedian and former medical resident Adam Kay's This Is Going to Hurt provides a no-holds-barred account of his time on the front lines of medicine. Hilarious, horrifying and heartbreaking by turns, this is everything you wanted to know -- and more than a few things you didn't -- about life on and off the hospital ward. And yes, it may leave a scar.

The range of environments in which people can survive is extensive, yet most of the natural world cannot support human life. The Biology of Human Survival identifies the key determinants of life or death in extreme environments from a physiologist's perspective, integrating modern concepts of stress, tolerance, and adaptation into explanations of life under Nature's most austere conditions. The book examines how individuals survive when faced with extremes of immersion, heat, cold or altitude, emphasizing the body's recognition of stress and the brain's role in optimizing physiological function in order to provide time to escape or to adapt. In illustrating how human biology adapts to extremes, the book also explains how we learn to cope by blending behavior and biology, first by trial and error, then by rigorous scientific observation, and finally by technological innovation. The book describes life-support technology and how it enables humans to enter once unendurable realm, from the depths of the ocean to the upper reaches of the atmosphere and beyond. Finally, it explores the role that advanced technology might play in special environments of the future, such as long journeys into space.

'The best deep dive into the diseases that plague us all today, and what to do to heal.' Jessie Inchauspe, The Glucose Goddess 'Good Energy is a powerful vision for a brighter future – for both people and the planet.' Jay Shetty 'A tour de force' Dr Mark Hyman

While it may seem that debates over euthanasia began with Jack Kervorkian, the practice of mercy killing extends back to Ancient Greece and beyond. In America, the debate has raged for well over a century. Now, in A Merciful End, Ian Dowbiggin offers the first full-scale historical account of one of the most controversial reform movements in America. Drawing on unprecedented access to the archives of the Euthanasia Society of America, interviews with important figures in the movement today, and flashpoint cases such as the tragic fate of Karen Ann Quinlan, Dowbiggin tells the dramatic story of the men and women who struggled throughout the twentieth century to change the nation's attitude--and its laws--regarding mercy killing. In tracing the history of the euthanasia movement, he documents its intersection with other progressive social causes: women's suffrage, birth control, abortion rights, as well as its uneasy pre-WWII alliance with eugenics. Such links brought euthanasia activists into fierce conflict with Judeo-Christian institutions who worried that "the right to die" might become a "duty to die." Indeed, Dowbiggin argues that by joining a sometimes overzealous quest to maximize human freedom with a desire to "improve" society, the euthanasia movement has been dogged by the fear that mercy killing could be extended to persons with disabilities, handicapped newborns, unconscious geriatric patients, lifelong criminals, and even the poor. Justified or not, such fears have stalled the movement, as more and more Americans now prefer better end-of-life care than wholesale changes in euthanasia laws. For anyone trying to decide whether euthanasia offers a humane alternative to prolonged suffering or violates the "sanctity of life," A Merciful End provides fascinating and much-needed historical context.

"All women need to read this book."—Dave Asprey, author of The Bulletproof Diet"Groundbreaking solutions for the common hormonal struggles women face both on and off birth control."—Amy Medling, founder of PCOS Diva and author of Healing PCOSA natural, effective program for restoring hormone balance, normalizing your period, and reversing the harmful side effects of ‘The Pill’—for the millions of women who take it for acne, PMS, menstrual cramps, PCOS, Endometriosis, and many more reasons other than contraception.Out of the 100 million women—almost 11 million in the United States alone—who are on the pill, roughly 60 percent take it for non-contraceptive reasons like painful periods, endometriosis, PCOS, and acne. While the birth control pill is widely prescribed as a quick-fix solution to a variety of women’s health conditions, taking it can also result in other more serious and dangerous health consequences. Did you know that women on the pill are more likely to be prescribed an antidepressant? That they are at significantly increased risk for autoimmune disease, heart attack, thyroid and adrenal disorders, and even breast and cervical cancer? That the pill can even cause vaginal dryness, unexplained hair loss, flagging libido, extreme fatigue, and chronic infection. As if women didn’t have enough to worry about, that little pill we’re taking to manage our symptoms is only making things worse.Jolene Brighten, ND, author of the groundbreaking new book Beyond the Pill, specializes in treating women’s hormone imbalances caused by the pill and shares her proven 30-day program designed to reverse the myriad of symptoms women experience every day—whether you choose to stay on the pill or not. The first book of its kind to target the birth control pill and the scientifically-proven symptoms associated with taking it, Beyond the Pill is an actionable plan for taking control, and will help readers: Locate the root cause of their hormonal issues, like estrogen dominance, low testosterone, and low progesterone Discover a pain-free, manageable period free of cramps, acne, stress, or PMS without the harmful side effects that come with the pill Detox the liver, support the adrenals and thyroid, heal the gut, reverse metabolic mayhem, boost fertility, and enhance mood Transition into a nutrition and supplement program, with more than 30 hormone-balancing recipesFeaturing simple diet and lifestyle interventions, Beyond the Pill is the first step to reversing the risky side effects of the pill, finally finding hormonal health, and getting your badass self back.

Gold Award Winner, 2024 Nonfiction Book Awards Runner-up, 2024 History category, San Francisco Book Festival Runner-up, 2024 General Non-Fiction, New York Book Festival For much of recorded history, people considered the heart to be the most important organ in the body. In cultures around the world, the heart—not the brain—was believed to be the location of intelligence, memory, emotion, and the soul. Over time, views on the purpose of the heart have transformed as people sought to understand the life forces it contains. Modern medicine and science dismissed what was once the king of the organs as a mere blood pump subservient to the brain, yet the heart remains a potent symbol of love and health and an important part of our cultural iconography. This book traces the evolution of our understanding of the heart from the dawn of civilization to the present. Vincent M. Figueredo—an accomplished cardiologist and expert on the history of the human heart—explores the role and significance of the heart in art, culture, religion, philosophy, and science across time and place. He examines how the heart really works, its many meanings in our emotional and daily lives, and what cutting-edge science is teaching us about this remarkable organ. Figueredo considers the science of heart disease, recent advancements in heart therapies, and what the future may hold. He highlights the emerging field of neurocardiology, which has found evidence of a “heart-brain connection” in mental and physical health, suggesting that ancient views hold more truth than moderns suspect. Ranging widely and deeply throughout human history, this book sheds new light on why the heart remains so central to our sense of self.

How eliminating “risk illiteracy” among doctors and patients will lead to better health care decision making.Contrary to popular opinion, one of the main problems in providing uniformly excellent health care is not lack of money but lack of knowledge—on the part of both doctors and patients. The studies in this book show that many doctors and most patients do not understand the available medical evidence. Both patients and doctors are “risk illiterate”—frequently unable to tell the difference between actual risk and relative risk. Further, unwarranted disparity in treatment decisions is the rule rather than the exception in the United States and Europe. All of this contributes to much wasted spending in health care.The contributors to Better Doctors, Better Patients, Better Decisions investigate the roots of the problem, from the emphasis in medical research on technology and blockbuster drugs to the lack of education for both doctors and patients. They call for a new, more enlightened health care, with better medical education, journals that report study outcomes completely and transparently, and patients in control of their personal medical records, not afraid of statistics but able to use them to make informed decisions about their treatments.

Psycho-Oncology was the first comprehensive text in the field of psychosocial oncology and remains the gold standard today. Written by 67 internationally known psychiatry and palliative care experts, the resource is truly an essential reference for all providers of palliative care.Joining Oxford Medicine Online this resource offers the best quality content in an easy-to-access format. Online only benefits include downloading images and figures to PowerPoint and downloading chapters to PDF.