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If it weren't for mitochondria, scientists argue, we'd all still be single-celled bacteria. Indeed, these tiny structures inside our cells are important beyond imagining. Without mitochondria, we would have no cell suicide, no sculpting of embryonic shape, no sexes, no menopause, no aging.In this fascinating and thought-provoking book, Nick Lane brings together the latest research in this exciting field to show how our growing insight into mitochondria has shed light on how complex life evolved, why sex arose (why don't we just bud?), and why we age and die. These findings are of fundamental importance, both in understanding life on Earth, but also in controlling our own illnesses, and delaying our degeneration and death. Readers learn that two billion years ago, mitochondria were probably bacteria living independent lives and that their capture within larger cells was a turning point in the evolution of life, enabling the development of complex organisms. Lane describes how mitochondria have their own DNA and that its genes mutate much faster than those in the nucleus. This high mutation rate lies behind our aging and certain congenital diseases. The latest research suggests that mitochondria play a key role in degenerative diseases such as cancer. We also discover that mitochondrial DNA is passed down almost exclusively via the female line. That's why it has been used by some researchers to trace human ancestry daughter-to-mother, to "Mitochondrial Eve," giving us vital information about our evolutionary history.Written by Nick Lane, a rising star in popular science, Power, Sex, Suicide is the first book for general readers on the nature and function of these tiny, yet fascinating structures.

After 30 Years, Obstetrics: Normal And Problem Pregnancies Remains Your Go-to Choice For Authoritative Guidance On Managing Today’s Obstetric Patient. International Experts Put The Latest Knowledge In This Specialty At Your Fingertips, With Current And Relevant Information On Everything From Fetal Origins Of Adult Disease, To Improving Global Maternal Health, To Important Topics In Day-to-day Obstetrical Practice. Highly Readable, Well-illustrated, And Easy To Understand, This Bestselling Obstetrics Reference Is An Ideal Tool For Residents And Clinicians. Take Advantage Of The Collective Wisdom Of Global Experts In The Field, Including Two New Editors— Drs. Vincenzo Berghella And William Grobman -- And Nearly 30 New Contributors. Gain A New Perspective On A Wide Range Of Today's Key Issues - All Evidence-based And Easy To Read. Sweeping Updates Throughout Including Four New Chapters: ‘vaginal Birth After Cesarean Delivery’; ‘placenta Accreta’; ‘obesity’; And ‘improving Global Maternal Health: Challenges And Opportunities’ New Glossary Of The Most Frequently Used Key Abbreviations For Easy Reference Expanded Use Of Bolded Statements And Key Points As Well As Additional Tables, Flow Diagrams, And Bulleted Lists Facilitates And Enhances The Mastery Of Each Chapter More Than 100 Images In The Obstetrical Ultrasound Chapter Provide An Important Resource For Normal And Abnormal Fetal Anatomy

The landmark New York Times best seller that reveals how the explosion of sugar in our diets has created an obesity epidemic, and what we can do to save ourselves. Robert Lustig is at the forefront of war against sugar — showing us that it's toxic, it's addictive, and it's everywhere because the food companies want it to be. His 90-minute YouTube video "Sugar: The Bitter Truth" has been viewed more than 7 million times. Now, in this landmark book, he documents the science and the politics that have led to personal misery and public crisis — the pandemic of obesity and chronic disease--over the last thirty years. In the late 1970s, when the U.S. government declared that we needed to get the fat out of our diets, the food industry responded by pumping in more sugar to make food more palatable (and more salable), and by removing the fiber to make food last longer on the shelf. The result has been a perfect storm for our health, disastrously altering our biochemistry to make us think we're starving, drive our eating habits out of our control, and turn us into couch potatoes. If we cannot control how we eat, it's because of the catastrophic excess of sugar in our diet--the resulting hormonal imbalances have rewired our brains! To help us lose weight and recover our health, Lustig presents strategies we can each use to readjust the key hormones that regulate hunger, reward, and stress, as well as societal strategies to improve the health of the next generation. With scientific rigor and even a little humor, Fat Chance categorically proves that "a calorie is not a calorie," and takes that knowledge to its logical conclusion--an overhaul of the global food system.

Editor of the award-winning site Feministing.com, Maya Dusenbery brings together scientific and sociological research, interviews with doctors and researchers, and personal stories from women across the country to provide the first comprehensive, accessible look at how sexism in medicine harms women today.In Doing Harm, Dusenbery explores the deep, systemic problems that underlie women’s experiences of feeling dismissed by the medical system. Women have been discharged from the emergency room mid-heart attack with a prescription for anti-anxiety meds, while others with autoimmune diseases have been labeled “chronic complainers” for years before being properly diagnosed. Women with endometriosis have been told they are just overreacting to “normal” menstrual cramps, while still others have “contested” illnesses like chronic fatigue syndrome and fibromyalgia that, dogged by psychosomatic suspicions, have yet to be fully accepted as “real” diseases by the whole of the profession.An eye-opening read for patients and health care providers alike, Doing Harm shows how women suffer because the medical community knows relatively less about their diseases and bodies and too often doesn’t trust their reports of their symptoms. The research community has neglected conditions that disproportionately affect women and paid little attention to biological differences between the sexes in everything from drug metabolism to the disease factors—even the symptoms of a heart attack. Meanwhile, a long history of viewing women as especially prone to “hysteria” reverberates to the present day, leaving women battling against a stereotype that they’re hypochondriacs whose ailments are likely to be “all in their heads.”Offering a clear-eyed explanation of the root causes of this insidious and entrenched bias and laying out its sometimes catastrophic consequences, Doing Harm is a rallying wake-up call that will change the way we look at health care for women.

Guardian columnist Dr Ben Goldacre takes us on a hilarious, invigorating and informative journey through the bad science we're fed by the worst of the hacks and the quacks! When Dr Ben Goldacre saw someone on daytime TV dipping her feet in an 'Aqua Detox' footbath, releasing her toxins into the water and turning it brown, he thought he'd try the same at home. 'Like some kind of Johnny Ball cum Witchfinder General', using his girlfriend's Barbie doll, he gently passed an electrical current through the warm salt water. It turned brown. In his words: 'before my very eyes, the world's first Detox Barbie was sat, with her feet in a pool of brown sludge, purged of a weekend's immorality.' Dr Ben Goldacre is the author of the 'Bad Science' column in the Guardian and his book is about all the 'bad science' we are constantly bombarded with in the media and in advertising. At a time when science is used to prove everything and nothing, everyone has their own 'bad science' moments -- from the useless pie-chart on the back of cereal packets to the use of the word 'visibly' in cosmetics ads.This book will help people to quantify their instincts -- that a lot of the so-called 'science' which appears in the media and in advertising is just wrong or misleading. Satirical and amusing -- and unafraid to expose the ridiculous -- it provides the reader with the facts they need to differentiate the good from the bad. Full of spleen, this is a hilarious, invigorating and informative journey through the world of 'bad science'.

**THE SUNDAY TIMES BESTSELLER**'You're amazing I could talk to you (Rahul) all day' Chris Evans'This is a gripping new book' The TimesWorld-leading neuroscientist and neurosurgeon Dr Rahul Jandial draws on his years of work with patients suffering from the most extreme cases of brain damage, disorders and illnesses to reveal what they can tell us about the science of the mind.From a languages teacher who has to choose whether to lose her ability to speak Spanish or English after brain surgery, to a former TV exec, now homeless, who discovers that his life-altering despondency is the result of a tumour, to a fainting teen who learns that deep breathing can mean the difference between life or death, these stories uncover the secret workings of the brain.Blending cutting-edge research and beautiful storytelling, Life Lessons from a Brain Surgeon is a vital resource on the best ways to boost your memory, control stress and emotions, minimize pain, unleash your creativity, raise smart kids and reduce the risk of Alzheimer's. This is a deeply practical and readable book, which will take you on an expedition through the anatomy of the most fascinating - and mysterious - of organs.

From the international bestselling author of Gut, an entertaining and highly informative book about how the body's organs work in tandem to keep us as healthy as we can be. In a world that is becoming ever louder and more complex, sometimes the best perspective is to look inward--at our own physicality. For thousands of years, our bodies have faced challenges and found their own unique ways to overcome them. What can we learn from these extraordinarily complex beings? In her new book, internationally renowned medical expert and star of Netflix's Hack Your Health Giulia Enders embarks on a journey of discovery into our inner workings, raising fundamental questions: What can the immune system teach us about security? How does the process of wound-healing inform our understanding of emotional recovery? What do we truly need to thrive? What are we capable of when we achieve peak health? How do we truly want to treat one another? Our bodies offer fascinating answers to all these questions, transforming our perspective on life itself. With the latest scientific insights and her unmatched talent for making complex concepts vividly accessible, Giulia Enders inspires a deep appreciation for something that is both intimately familiar yet profoundly mysterious--the very basis for how we find our happiest selves.

Market: Pharmacy and medical students; neuroscientists; neurologists; pharmacologists Updated edition has an attractive full-color design with more illustrations Includes numerous Fact Boxes to help reinforce learning

An electrifying memoir of one woman's extraordinary effort to save her husband's life-and the discovery of a forgotten cure that has the potential to save millions more. "A memoir that reads like a thriller." -New York Times Book Review "A fascinating and terrifying peek into the devastating outcomes of antibiotic misuse-and what happens when standard health care falls short." -Scientific American Epidemiologist Steffanie Strathdee and her husband, psychologist Tom Patterson, were vacationing in Egypt when Tom came down with a stomach bug. What at first seemed like a case of food poisoning quickly turned critical, and by the time Tom had been transferred via emergency medevac to the world-class medical center at UC San Diego, where both he and Steffanie worked, blood work revealed why modern medicine was failing: Tom was fighting one of the most dangerous, antibiotic-resistant bacteria in the world. Frantic, Steffanie combed through research old and new and came across phage therapy: the idea that the right virus, aka "the perfect predator," can kill even the most lethal bacteria. Phage treatment had fallen out of favor almost 100 years ago, after antibiotic use went mainstream. Now, with time running out, Steffanie appealed to phage researchers all over the world for help. She found allies at the FDA, researchers from Texas A&M, and a clandestine Navy biomedical center -- and together they resurrected a forgotten cure. A nail-biting medical mystery, The Perfect Predator is a story of love and survival against all odds, and the (re)discovery of a powerful new weapon in the global superbug crisis.