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Reader-friendly Cell Biology, 4th Edition, provides a concise but comprehensive foundation for students entering research or health care career paths. Award winning illustrations help readers quickly grasp general principles. The authors have thoroughly updated this popular text to provide readers with the current understanding of the principles of normal cellular function along with examples of how molecular defects predispose to human disease. Major new themes in the 4th edition include the roles of intrinsically disordered polypeptides and phase separation in cellular functions, the influence of new molecular structures on understanding mechanisms, and the impact of exciting new methods―from single cell RNA sequencing to second generation super resolution fluorescence microscopy―on advancing our understanding.Clear, readable explanations provide a concise story about how cells function at the molecular level.An intuitive chapter flow starts with genome organization, gene expression, and RNA processing as a foundation for understanding every aspect of cellular function and physiology.Brings cellular biology to life for students interested in medical science by explaining how mutations in genes can compromise virtually every cellular system and predispose to human disease. Knowledge of cell biology has led to new treatments for cancer, heart failure, cystic fibrosis, and many other diseases.Unique illustrations with realistic proportions and relationships explain every cellular process including the assembly of SARS CoV-2, the structures attaching mitotic chromosomes to microtubules, the mechanism of DNA replication and how pumps, carriers and channels orchestrate physiological processes from synaptic transmission to cellular volume regulation.Covers exciting breakthroughs such as SMC motor proteins actively organizing chromosomal DNA, TOR kinases regulating metabolism, new types of immunotherapy for cancer treatment, mechanisms regulating fast axonal transport and their relation to neurodegenerative diseases, how completion of DNA replication sets the time for cells to enter mitosis, how a cascade of signals specifies the site of cell division, and newly understood pathways of normal and pathological cell death.Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

#1 NEW YORK TIMES BESTSELLER • Writing with all the passion of Love Story and power of The Class, Erich Segal sweeps us into the lives of the Harvard Medical School's class of 1962. His stunning novel reveals the making of doctors—what makes them tick, scheme, hurt . . . and love.From the crucible of med school’s merciless training through the demanding hours of internship and residency to the triumphs—and sometimes tragedies—beyond, Doctors brings to vivid life the men and women who seek to heal but who must first walk through fire.At the novel’s heart is the unforgettable relationship of Barney Livingston and Laura Castellano, childhood friends who separately find unsettling celebrity and unsatisfying love—until their friendship ripens into passion.Yet even their devotion to each other, even their medical gifts may not be enough to save the one life they treasure above all others. Doctors—heartbreaking, witty, inspiring, and utterly, grippingly real—is a vibrant portrait that culminates in a murder, a trial . . . and a miracle.

Paperback. Pub Date :2014-01-02 Pages: 336 Language: English Publisher: HarperCollins UK Sugar is toxic. addictive and everywhere So what chance do you have of living sugar-freeWith busy lives and little time left for cooking we find ourselves. relying on a diet of processed food But this is what's responsible for our chronically expanding waistlines. soaring levels of diabetes and a catalogue of diseases.Dr Robert Lustig reveals the truth about our sugar-laden food:. Why conventional low-fat weight loss advice won't work: not every calorie is the same. and skipping lunch doesn't mean it's ok to eat dessert Why too much sugar can cause serious illness even if you are not overweight How the food industry is filling our diets with hidden sugars - and which foods you must cut out to avoid themHow governments are complacent about. and even complicit in. exacerbating our food deb...

#1 NEW YORK TIMES BESTSELLER • OPRAH’S BOOK CLUB PICK • ONE OF GQ's TOP 50 BOOKS OF LITERARY JOURNALISM IN THE 21st CENTURY • The heartrending story of a midcentury American family with twelve children, six of them diagnosed with schizophrenia, that became science's great hope in the quest to understand the disease."Reads like a medical detective journey and sheds light on a topic so many of us face: mental illness." —Oprah WinfreyDon and Mimi Galvin seemed to be living the American dream. After World War II, Don's work with the Air Force brought them to Colorado, where their twelve children perfectly spanned the baby boom: the oldest born in 1945, the youngest in 1965. In those years, there was an established script for a family like the Galvins--aspiration, hard work, upward mobility, domestic harmony--and they worked hard to play their parts. But behind the scenes was a different story: psychological breakdown, sudden shocking violence, hidden abuse. By the mid-1970s, six of the ten Galvin boys, one after another, were diagnosed as schizophrenic. How could all this happen to one family?What took place inside the house on Hidden Valley Road was so extraordinary that the Galvins became one of the first families to be studied by the National Institute of Mental Health. Their story offers a shadow history of the science of schizophrenia, from the era of institutionalization, lobotomy, and the schizophrenogenic mother to the search for genetic markers for the disease, always amid profound disagreements about the nature of the illness itself. And unbeknownst to the Galvins, samples of their DNA informed decades of genetic research that continues today, offering paths to treatment, prediction, and even eradication of the disease for future generations.With clarity and compassion, bestselling and award-winning author Robert Kolker uncovers one family's unforgettable legacy of suffering, love, and hope.

A NEW YORK TIMES BESTSELLERFrom a renowned behavioral neuroscientist and recovering addict, a rare page-turning work of science that draws on personal insights to reveal how drugs work, the dangerous hold they can take on the brain, and the surprising way to combat today's epidemic of addiction.Judith Grisel was a daily drug user and college dropout when she began to consider that her addiction might have a cure, one that she herself could perhaps discover by studying the brain. Now, after twenty-five years as a neuroscientist, she shares what she and other scientists have learned about addiction, enriched by captivating glimpses of her personal journey.In Never Enough, Grisel reveals the unfortunate bottom line of all regular drug use: there is no such thing as a free lunch. All drugs act on the brain in a way that diminishes their enjoyable effects and creates unpleasant ones with repeated use. Yet they have their appeal, and Grisel draws on anecdotes both comic and tragic from her own days of using as she limns the science behind the love of various drugs, from marijuana to alcohol, opiates to psychedelics, speed to spice.With more than one in five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide, and Grisel delves with compassion into the science of this scourge. She points to what is different about the brains of addicts even before they first pick up a drink or drug, highlights the changes that take place in the brain and behavior as a result of chronic using, and shares the surprising hidden gifts of personality that addiction can expose. She describes what drove her to addiction, what helped her recover, and her belief that a “cure” for addiction will not be found in our individual brains but in the way we interact with our communities.Set apart by its color, candor, and bell-clear writing, Never Enough is a revelatory look at the roles drugs play in all of our lives and offers crucial new insight into how we can solve the epidemic of abuse.

“Nicole Jardim walks the talk, and I am confident that Fix Your Period will help ignite the hormone balance you are seeking and restore your vitality.” --Sara Gottfried, MD, New York Times bestselling author of The Hormone CureA life-changing step-by-step natural protocol to ignite lasting hormone balance and improve everything from PMS, period pain, and heavy periods to irregular cycles and missing periods, from Nicole Jardim, certified women’s health coach and co-host of the podcast The Period Party.For most women, getting their period sucks. Bloating. Cramps. Acne. Aches. Moodiness. Messiness. No wonder we call it The Curse! For many, it’s not just an inconvenience—it’s a colossal life disruption, forcing them to miss work, school, appointments, or dates.We’ve been encouraged to medicate away common period problems with birth control and ibuprofen, and just survive the mood swings as best we can. But as Nicole Jardim explains, periods aren’t a nuisance, they’re information. When you learn to decode your period (or lack thereof), you’ll be able to recognize the underlying hormone imbalances causing your period problems and know how to fix them naturally with Jardim’s proven six-week protocol to resolve even the most challenging hormone imbalances and menstruation issues.Joining the ranks of books by Jolene Brighten, Sara Gottfried, and Aviva Romm, Nicole Jardim’s Fix Your Period is essential for women plagued by PMS, irregular, painful, or heavy periods, PCOS, Endometriosis, or fibroids—and for anyone who wants to take charge of her hormonal health—and regain control of her life—naturally.

Describes the search for the genes that control cancer, explains the difficulties of research in molecular biology, and assesses progress towards a more detailed understanding of cancer

Gold Award Winner, 2024 Nonfiction Book Awards Runner-up, 2024 History category, San Francisco Book Festival Runner-up, 2024 General Non-Fiction, New York Book Festival For much of recorded history, people considered the heart to be the most important organ in the body. In cultures around the world, the heart—not the brain—was believed to be the location of intelligence, memory, emotion, and the soul. Over time, views on the purpose of the heart have transformed as people sought to understand the life forces it contains. Modern medicine and science dismissed what was once the king of the organs as a mere blood pump subservient to the brain, yet the heart remains a potent symbol of love and health and an important part of our cultural iconography. This book traces the evolution of our understanding of the heart from the dawn of civilization to the present. Vincent M. Figueredo—an accomplished cardiologist and expert on the history of the human heart—explores the role and significance of the heart in art, culture, religion, philosophy, and science across time and place. He examines how the heart really works, its many meanings in our emotional and daily lives, and what cutting-edge science is teaching us about this remarkable organ. Figueredo considers the science of heart disease, recent advancements in heart therapies, and what the future may hold. He highlights the emerging field of neurocardiology, which has found evidence of a “heart-brain connection” in mental and physical health, suggesting that ancient views hold more truth than moderns suspect. Ranging widely and deeply throughout human history, this book sheds new light on why the heart remains so central to our sense of self.

It lurks in the corner of our imagination, almost beyond our ability to see it: the possibility that a tear in the fabric of life could open up without warning, upending a house, a skyscraper, or a civilization.Today, nine out of ten Americans live in places at significant risk of earthquakes, hurricanes, tornadoes, terrorism, or other disasters. Tomorrow, some of us will have to make split-second choices to save ourselves and our families. How will we react? What will it feel like? Will we be heroes or victims? Will our upbringing, our gender, our personality–anything we’ve ever learned, thought, or dreamed of–ultimately matter?Amanda Ripley, an award-winning journalist for Time magazine who has covered some of the most devastating disasters of our age, set out to discover what lies beyond fear and speculation. In this magnificent work of investigative journalism, Ripley retraces the human response to some of history’s epic disasters, from the explosion of the Mont Blanc munitions ship in 1917–one of the biggest explosions before the invention of the atomic bomb–to a plane crash in England in 1985 that mystified investigators for years, to the journeys of the 15,000 people who found their way out of the World Trade Center on September 11, 2001. Then, to understand the science behind the stories, Ripley turns to leading brain scientists, trauma psychologists, and other disaster experts, formal and informal, from a Holocaust survivor who studies heroism to a master gunfighter who learned to overcome the effects of extreme fear.Finally, Ripley steps into the dark corners of her own imagination, having her brain examined by military researchers and experiencing through realistic simulations what it might be like to survive a plane crash into the ocean or to escape a raging fire.Ripley comes back with precious wisdom about the surprising humanity of crowds, the elegance of the brain’s fear circuits, and the stunning inadequacy of many of our evolutionary responses. Most unexpectedly, she discovers the brain’s ability to do much, much better, with just a little help.The Unthinkable escorts us into the bleakest regions of our nightmares, flicks on a flashlight, and takes a steady look around. Then it leads us home, smarter and stronger than we were before.

Learn how to navigate your life with endometriosis in this essential and hopeful guide--including tools and strategies to gain a deeper understanding of your body and manage chronic pain through diet, movement, stress management, and more.Endometriosis isn’t just about having “painful periods.” It can be a complex, debilitating, and all-encompassing condition that impacts one’s mental health, relationships, and career. Endo affects 1 in 10 women and girls across the globe, but even after receiving a diagnosis, many are still left in the dark about their condition. In Know Your Endo, Jessica Murnane breaks through the misinformation and gives essential guidance, encouragement, and practical lifestyle tools to help those living with endo have more control and feel better in their bodies.In this empowering and heartfelt guide, Jessica, who suffers from endo herself, shares a progressive five-week plan focused on learning a new management tool each week. Including sections on diet (with recipes!), movement, products, and personal-care rituals, Know Your Endo eases readers into a new lifestyle and arms them with the information needed to truly understand their condition. Insights and help from endometriosis doctors and experts are woven throughout, as well as first-person accounts of how endo can impact every aspect of your life.Finally, there’s a resource for all people suffering in silence from this chronic condition offering what they need most: hope.