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von Bessel van der Kolk

Essential reading for anyone interested in understanding and treating traumatic stress and the scope of its impact on society.” —Alexander McFarlane, Director of the Centre for Traumatic Stress Studies A pioneering researcher transforms our understanding of trauma and offers a bold new paradigm for healing in this New York Times Science bestseller Trauma is a fact of life. Veterans and their families deal with the painful aftermath of combat; one in five Americans has been molested; one in four grew up with alcoholics; one in three couples have engaged in physical violence. Dr. Bessel van der Kolk, one of the world’s foremost experts on trauma, has spent over three decades working with survivors. In The Body Keeps the Score, he uses recent scientific advances to show how trauma literally reshapes both body and brain, compromising sufferers’ capacities for pleasure, engagement, self-control, and trust. He explores innovative treatments—from neurofeedback and meditation to sports, drama, and yoga—that offer new paths to recovery by activating the brain’s natural neuroplasticity. Based on Dr. van der Kolk’s own research and that of other leading specialists, The Body Keeps the Score exposes the tremendous power of our relationships both to hurt and to heal—and offers new hope for reclaiming lives.

von Thomas D. Pollard MD, William C. Earnshaw PhD FRS, Jennifer Lippincott-Schwartz PhD, Graham Johnson MA PhD CMI

Reader-friendly Cell Biology, 4th Edition, provides a concise but comprehensive foundation for students entering research or health care career paths. Award winning illustrations help readers quickly grasp general principles. The authors have thoroughly updated this popular text to provide readers with the current understanding of the principles of normal cellular function along with examples of how molecular defects predispose to human disease. Major new themes in the 4th edition include the roles of intrinsically disordered polypeptides and phase separation in cellular functions, the influence of new molecular structures on understanding mechanisms, and the impact of exciting new methods―from single cell RNA sequencing to second generation super resolution fluorescence microscopy―on advancing our understanding.Clear, readable explanations provide a concise story about how cells function at the molecular level.An intuitive chapter flow starts with genome organization, gene expression, and RNA processing as a foundation for understanding every aspect of cellular function and physiology.Brings cellular biology to life for students interested in medical science by explaining how mutations in genes can compromise virtually every cellular system and predispose to human disease. Knowledge of cell biology has led to new treatments for cancer, heart failure, cystic fibrosis, and many other diseases.Unique illustrations with realistic proportions and relationships explain every cellular process including the assembly of SARS CoV-2, the structures attaching mitotic chromosomes to microtubules, the mechanism of DNA replication and how pumps, carriers and channels orchestrate physiological processes from synaptic transmission to cellular volume regulation.Covers exciting breakthroughs such as SMC motor proteins actively organizing chromosomal DNA, TOR kinases regulating metabolism, new types of immunotherapy for cancer treatment, mechanisms regulating fast axonal transport and their relation to neurodegenerative diseases, how completion of DNA replication sets the time for cells to enter mitosis, how a cascade of signals specifies the site of cell division, and newly understood pathways of normal and pathological cell death.Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

von Matthew Walker

Sleep is one of the most important aspects of our life, health and longevity and yet it is increasingly neglected in twenty-first-century society, with devastating consequences: every major disease in the developed world - Alzheimer's, cancer, obesity, diabetes - has very strong causal links to deficient sleep.Until very recently, science had no answer to the question of why we sleep, or what good it served, or why its absence is so damaging to our health. Compared to the other basic drives in life - eating, drinking, and reproducing - the purpose of sleep remained elusive.Now, in this book, the first of its kind written by a scientific expert, Professor Matthew Walker explores twenty years of cutting-edge research to solve the mystery of why sleep matters. Looking at creatures from across the animal kingdom as well as major human studies, Why We Sleep delves in to everything from what really happens during REM sleep to how caffeine and alcohol affect sleep and why our sleep patterns change across a lifetime, transforming our appreciation of the extraordinary phenomenon that safeguards our existence.

von Dr Rangan Chatterjee

THE LATEST BOOK FROM THE AUTHOR OF THE SUNDAY TIMES #1 BESTSELLER FEEL BETTER IN 5'This is not a diet book. This is a whole new way of looking at what, why and how we eat and helps you design your own plan to build a better, healthier relationship with food' Fearne Cotton'A book with practical simple tips for everyone!' Tim Spector'It is a beautiful book and has so much in it to help us feel good and prioritise our happiness and health' Dr Gemma Newman'One of the most influential doctors in the country' Chris Evans_________________________________________________________________________It's more important than ever before that we get in shape, stay healthy and live well - Dr Chatterjee is back to show you how.Weight loss isn't a race. It isn't one size fits all. Drawing on twenty years of experience as a GP, Dr Rangan Chatterjee has created a conscious, long-lasting approach to weight loss that goes far beyond fad diets and helps to find the best solutions that work for you. Packed with quick and easy interventions this book will help you:1. Understand the effects of what, why, when, where and how we eat2. Discover the root cause of your weight gain3. Nourish your body without any crash diets or gruelling workouts4. Build a toolbox of techniques to help you lose weight, for goodWith Feel Great, Lose Weight you can make sustainable, medically-approved lifestyle changes and become a more energised, confident and healthy you._________________________________________________________________________'A blame-free book' Telegraph'This book is extremely practical, insightful and easy-to-follow' The Happy Pears

von Casey Means

'The best deep dive into the diseases that plague us all today, and what to do to heal.' Jessie Inchauspe, The Glucose Goddess 'Good Energy is a powerful vision for a brighter future – for both people and the planet.' Jay Shetty 'A tour de force' Dr Mark Hyman

von Angela Garbes

A candid, feminist, and personal deep dive into the science and culture of pregnancy and motherhoodLike most first-time mothers, Angela Garbes was filled with questions when she became pregnant. What exactly is a placenta and how does it function? How does a body go into labor? Why is breast best? Is wine totally off-limits? But as she soon discovered, it’s not easy to find satisfying answers. Your obstetrician will cautiously quote statistics; online sources will scare you with conflicting and often inaccurate data; and even the most trusted books will offer information with a heavy dose of judgment. To educate herself, the food and culture writer embarked on an intensive journey of exploration, diving into the scientific mysteries and cultural attitudes that surround motherhood to find answers to questions that had only previously been given in the form of advice about what women ought to do—rather than allowing them the freedom to choose the right path for themselves.In Like a Mother, Garbes offers a rigorously researched and compelling look at the physiology, biology, and psychology of pregnancy and motherhood, informed by in-depth reportage and personal experience. With the curiosity of a journalist, the perspective of a feminist, and the intimacy and urgency of a mother, she explores the emerging science behind the pressing questions women have about everything from miscarriage to complicated labors to postpartum changes. The result is a visceral, full-frontal look at what’s really happening during those nine life-altering months, and why women deserve access to better care, support, and information.Infused with humor and born out of awe, appreciation, and understanding of the female body and its strength, Like a Mother debunks common myths and dated assumptions, offering guidance and camaraderie to women navigating one of the biggest and most profound changes in their lives.

von Carl Hart

High Price is the harrowing and inspiring memoir of neuroscientist Carl Hart, a leading researcher in the field of drug addiction, who grew up in one of Miami’s toughest neighborhoods and, determined to make a difference as an adult, tirelessly applies his scientific training to help save real lives. WINNER OF THE PEN/E. O. WILSON LITERARY SCIENCE WRITING AWARD Young Carl didn't see the value of school, studying just enough to keep him on the basketball team. Today, he is a cutting-edge neuroscientist—Columbia University’s first tenured African American professor in the sciences—whose landmark, controversial research is redefining our understanding of addiction. In this provocative and eye-opening memoir, Dr. Carl Hart recalls his journey of self-discovery, how he escaped a life of crime and drugs and avoided becoming one of the crack addicts he now studies. Interweaving past and present, Hart goes beyond the hype as he examines the relationship between drugs and pleasure, choice, and motivation, both in the brain and in society. His findings shed new light on common ideas about race, poverty, and drugs, and explain why current policies are failing.

von Kathryn Mannix

For readers of Atul Gawande and Paul Kalanithi, a palliative care doctor's breathtaking stories from 30 years spent caring for the dying.Modern medical technology is allowing us to live longer and fuller lives than ever before. And for the most part, that is good news. But with changes in the way we understand medicine come changes in the way we understand death. Once a familiar, peaceful, and gentle -- if sorrowful -- transition, death has come to be something from which we shield our eyes, as we prefer to fight desperately against it rather than accept its inevitability.Dr. Kathryn Mannix has studied and practiced palliative care for thirty years. In With the End in Mind , she shares beautifully crafted stories from a lifetime of caring for the dying, and makes a compelling case for the therapeutic power of approaching death not with trepidation, but with openness, clarity, and understanding.Weaving the details of her own experiences as a caregiver through stories of her patients, their families, and their distinctive lives, Dr. Mannix reacquaints us with the universal, but deeply personal, process of dying. With insightful meditations on life, death, and the space between them, With the End in Mind describes the possibility of meeting death gently, with forethought and preparation, and shows the unexpected beauty, dignity, and profound humanity of life coming to an end.

von Gabor Mate, M.D.

In This Accessible And Groundbreaking Book -- Filled With The Moving Stories Of Real People -- Medical Doctor And Bestselling Author Of Scattered Minds, Gabor Maté, Shows That Emotion And Psychological Stress Play A Powerful Role In The Onset Of Chronic Illness. Western Medicine Achieves Spectacular Triumphs When Dealing With Acute Conditions Such As Fractured Bones Or Life-threatening Infections. It Is Less Successful Against Ailments Not Susceptible To The Quick Ministrations Of Scalpel, Antibiotic Or Miracle Drug. Trained To Consider Mind And Body Separately, Physicians Are Often Helpless In Arresting The Advance Of Most Of The Chronic Diseases, Such As Breast Cancer, Rheumatoid Arthritis, Crohn’s Disease, Multiple Sclerosis, Fibromyalgia, And Even Alzheimer’s Disease. Gabor Maté Has Found That In All Of These Chronic Conditions, There Is A Common Thread: People Afflicted By These Diseases Have Led Lives Of Excessive Stress, Often Invisible To The Individuals Themselves. From An Early Age, Many Of Us Develop A Psychological Coping Style That Keeps Us Out Of Touch With The Signs Of Stress. So-called Negative Emotions, Particularly Anger, Are Suppressed. Dr. Maté Writes With Great Conviction That Knowledge Of How Stress And Disease Are Connected Is Essential To Prevent Illness In The First Place, Or To Facilitate Healing. When The Body Says No Is An Impressive Contribution To Current Research On The Physiological Connection Between Life’s Stresses And Emotions And The Body Systems Governing Nerves, Immune Apparatus And Hormones. With Great Compassion And Erudition, Gabor Maté Demystifies Medical Science And, As He Did In Scattered Minds, Invites Us All To Be Our Own Health Advocates. Excerpt From When The Body Says No “only An Intellectual Luddite Would Deny The Enormous Benefits That Have Accrued To Humankind From The Scrupulous Application Of Scientific Methods. But Not All Aspects Of Illness Can Be Reduced To Facts Verified By Double-blind Studies And By The Strictest Scientific Techniques. We Confine Ourselves To A Narrow Realm Indeed If We Exclude From Accepted Knowledge The Contributions Of Human Experience And Insight. . . . “in 1892 William Osler, One Of The Greatest Physicians Of All Time, Suspected Rheumatoid Arthritis To Be A Stress-related Disorder. Today Rheumatology All But Ignores That Wisdom, Despite The Supporting Scientific Evidence That Has Accumulated In The 110 Years Since Osler First Published His Text. That Is Where The Narrow Scientific Approach Has Brought The Practice Of Medicine. Elevating Modern Science To Be The Final Arbiter Of Our Sufferings, We Have Been Too Eager To Discard The Insights Of Previous Ages.” From The Hardcover Edition.

von Katherine Eban

A NEW YORK TIMES BESTSELLER * New York Times Notable Book * Best Book of the Year: New York Public Library, Kirkus Reviews, Science FridayWith a new postscript by the authorFrom an award-winning journalist, an explosive narrative investigation of the generic drug boom that reveals fraud and life-threatening dangers on a global scale—The Jungle for pharmaceuticalsMany have hailed the widespread use of generic drugs as one of the most important public-health developments of the twenty-first century. Today, almost 90 percent of our pharmaceutical market is comprised of generics, the majority of which are manufactured overseas. We have been reassured by our doctors, our pharmacists and our regulators that generic drugs are identical to their brand-name counterparts, just less expensive. But is this really true?Katherine Eban’s Bottle of Lies exposes the deceit behind generic-drug manufacturing—and the attendant risks for global health. Drawing on exclusive accounts from whistleblowers and regulators, as well as thousands of pages of confidential FDA documents, Eban reveals an industry where fraud is rampant, companies routinely falsify data, and executives circumvent almost every principle of safe manufacturing to minimize cost and maximize profit, confident in their ability to fool inspectors. Meanwhile, patients unwittingly consume medicine with unpredictable and dangerous effects.The story of generic drugs is truly global. It connects middle America to China, India, sub-Saharan Africa and Brazil, and represents the ultimate litmus test of globalization: what are the risks of moving drug manufacturing offshore, and are they worth the savings?A decade-long investigation with international sweep, high-stakes brinkmanship and big money at its core, Bottle of Lies reveals how the world’s greatest public-health innovation has become one of its most astonishing swindles.