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In this paradigm-shifting book from acclaimed Harvard Medical School doctor and one of TIME magazine's 100 most influential people on earth, Dr. David Sinclair reveals that everything we think we know about ageing is wrong, and shares the surprising, scientifically-proven methods that can help readers live younger, longer. For decades, the medical community has looked to a variety of reasons for why we age, and the consensus is that no one dies of old age; they die of age-related diseases. That's because ageing is not a disease - it is inevitable.But what if everything you think you know about ageing is wrong?What if ageing is a disease? And that disease is curable.In THE EVOLUTION OF AGEING, Dr. David Sinclair, one of the world's foremost authorities on genetics and ageing, argues just that. He has dedicated his life's work to chasing more than a longer lifespan - he wants to enable people to live longer, healthier, and disease-free well into our hundreds. In this book, he reveals a bold new theory of ageing, one that pinpoints a root cause of ageing that lies in an ancient genetic survival circuit. This genetic trick - a circuit designed to halt reproduction in order to repair damage to the genome -has enabled earth's early microcosms to survive and evolve into more advanced organisms. But this same survival circuit is the reason we age: as genetic damage accumulates over our lifespans from UV rays, environmental toxins, and unhealthy diets, our genome is overwhelmed, causing gray hair, wrinkles, achy joints, heart issues, dementia, and, ultimately, death.But genes aren't our destiny; we have more control over them than we've been taught to believe. We can't change our DNA, but we can harness the power of the epigenome to realise the true potential of our genes. Drawing on his cutting-edge findings at the forefront of medical research, Dr. Sinclair will provide a scientifically-proven roadmap to reverse the genetic clock by activating our vitality genes, so we can live younger longer. Readers will discover how a few simple lifestyle changes - like intermittent fasting, avoiding too much animal protein, limiting sugar, avoiding x-rays, exercising with the right intensity, and even trying cold therapy - can activate our vitality genes. Dr. Sinclair ends the book with a look to the near future, exploring what the world might look like - and what will need to change - when we are all living well to 120 or more.Dr. Sinclair takes what we have long accepted as the limits of human potential and mortality and turns them into choices. THE EVOLUTION OF AGEING is destined to be the biggest book on genes, biology, and longevity of this decade.

Sleep is one of the most important aspects of our life, health and longevity and yet it is increasingly neglected in twenty-first-century society, with devastating consequences: every major disease in the developed world - Alzheimer's, cancer, obesity, diabetes - has very strong causal links to deficient sleep.Until very recently, science had no answer to the question of why we sleep, or what good it served, or why its absence is so damaging to our health. Compared to the other basic drives in life - eating, drinking, and reproducing - the purpose of sleep remained elusive.Now, in this book, the first of its kind written by a scientific expert, Professor Matthew Walker explores twenty years of cutting-edge research to solve the mystery of why sleep matters. Looking at creatures from across the animal kingdom as well as major human studies, Why We Sleep delves in to everything from what really happens during REM sleep to how caffeine and alcohol affect sleep and why our sleep patterns change across a lifetime, transforming our appreciation of the extraordinary phenomenon that safeguards our existence.

The range of environments in which people can survive is extensive, yet most of the natural world cannot support human life. The Biology of Human Survival identifies the key determinants of life or death in extreme environments from a physiologist's perspective, integrating modern concepts of stress, tolerance, and adaptation into explanations of life under Nature's most austere conditions. The book examines how individuals survive when faced with extremes of immersion, heat, cold or altitude, emphasizing the body's recognition of stress and the brain's role in optimizing physiological function in order to provide time to escape or to adapt. In illustrating how human biology adapts to extremes, the book also explains how we learn to cope by blending behavior and biology, first by trial and error, then by rigorous scientific observation, and finally by technological innovation. The book describes life-support technology and how it enables humans to enter once unendurable realm, from the depths of the ocean to the upper reaches of the atmosphere and beyond. Finally, it explores the role that advanced technology might play in special environments of the future, such as long journeys into space.

"All women need to read this book."—Dave Asprey, author of The Bulletproof Diet"Groundbreaking solutions for the common hormonal struggles women face both on and off birth control."—Amy Medling, founder of PCOS Diva and author of Healing PCOSA natural, effective program for restoring hormone balance, normalizing your period, and reversing the harmful side effects of ‘The Pill’—for the millions of women who take it for acne, PMS, menstrual cramps, PCOS, Endometriosis, and many more reasons other than contraception.Out of the 100 million women—almost 11 million in the United States alone—who are on the pill, roughly 60 percent take it for non-contraceptive reasons like painful periods, endometriosis, PCOS, and acne. While the birth control pill is widely prescribed as a quick-fix solution to a variety of women’s health conditions, taking it can also result in other more serious and dangerous health consequences. Did you know that women on the pill are more likely to be prescribed an antidepressant? That they are at significantly increased risk for autoimmune disease, heart attack, thyroid and adrenal disorders, and even breast and cervical cancer? That the pill can even cause vaginal dryness, unexplained hair loss, flagging libido, extreme fatigue, and chronic infection. As if women didn’t have enough to worry about, that little pill we’re taking to manage our symptoms is only making things worse.Jolene Brighten, ND, author of the groundbreaking new book Beyond the Pill, specializes in treating women’s hormone imbalances caused by the pill and shares her proven 30-day program designed to reverse the myriad of symptoms women experience every day—whether you choose to stay on the pill or not. The first book of its kind to target the birth control pill and the scientifically-proven symptoms associated with taking it, Beyond the Pill is an actionable plan for taking control, and will help readers: Locate the root cause of their hormonal issues, like estrogen dominance, low testosterone, and low progesterone Discover a pain-free, manageable period free of cramps, acne, stress, or PMS without the harmful side effects that come with the pill Detox the liver, support the adrenals and thyroid, heal the gut, reverse metabolic mayhem, boost fertility, and enhance mood Transition into a nutrition and supplement program, with more than 30 hormone-balancing recipesFeaturing simple diet and lifestyle interventions, Beyond the Pill is the first step to reversing the risky side effects of the pill, finally finding hormonal health, and getting your badass self back.

From the international bestselling author of Gut, an entertaining and highly informative book about how the body's organs work in tandem to keep us as healthy as we can be. In a world that is becoming ever louder and more complex, sometimes the best perspective is to look inward--at our own physicality. For thousands of years, our bodies have faced challenges and found their own unique ways to overcome them. What can we learn from these extraordinarily complex beings? In her new book, internationally renowned medical expert and star of Netflix's Hack Your Health Giulia Enders embarks on a journey of discovery into our inner workings, raising fundamental questions: What can the immune system teach us about security? How does the process of wound-healing inform our understanding of emotional recovery? What do we truly need to thrive? What are we capable of when we achieve peak health? How do we truly want to treat one another? Our bodies offer fascinating answers to all these questions, transforming our perspective on life itself. With the latest scientific insights and her unmatched talent for making complex concepts vividly accessible, Giulia Enders inspires a deep appreciation for something that is both intimately familiar yet profoundly mysterious--the very basis for how we find our happiest selves.

“Overdosed America reveals the greed and corruption that drive health care costs skyward and now threaten the public health. Before you see a doctor, you should read this book.” —Eric Schlosser, author of Fast Food Nation Using the examples of Vioxx, Celebrex, cholesterol-lowering statin drugs, and anti-depressants, Overdosed America shows that at the heart of the current crisis in American medicine lies the commercialization of medical knowledge itself For twenty years, John Abramson, M.D., cared for patients of all ages in a small town north of Boston. But increasingly his role as family doctor was undermined as pressure mounted to use the latest drugs and high-tech solutions for nearly every problem. Drawing on his background in statistics and health policy research, he began to investigate the radical changes that were quietly taking place in American medicine. At the heart of the crisis, he found, lies the changed purpose of medical knowledge—from seeking to optimize health to searching for the greatest profits. The lack of transparency that has become normal in commercially sponsored medical research now taints the scientific evidence published in even our most prestigious medical journals. And unlike the recent scandals in other industries that robbed Americans of money and jobs, this one is undermining our health. Commercial distortion pervades the information that doctors rely upon to guide the prevention and treatment of common health problems, from heart disease to stroke, osteoporosis, diabetes, and osteoarthritis. The good news, as Dr. Abramson explains, is that the real scientific evidence shows that many of the things that you can do to protect and preserve your own health are far more effective than what the drug companies' top-selling products can do for you—which is why the drug companies work so hard to keep this information under wraps. In what is sure to be one of the most important and eye-opening books you or your doctor will ever read, John Abramson offers conclusive evidence that American medicine has broken its promise to best improve our health and is squandering more than $500 billion each year in the process.

Evolutionary thinking provides insights into many different areas in the research and practice of medicine and public health. It takes specialties such as medical microbiology, epidemiology, oncology, gynecology, and psychiatry that had become increasingly siloed and places them in a larger framework. This foundational structure enables students to view medical knowledge as an integrated whole, underpinned by general principles rather than a loose collection of disparate facts. The discipline of evolutionary medicine continues to advance rapidly as new results come in showing where the insights pay off and where they do not. Its conceptual foundations have also been strengthened in papers not yet reflected in the textbooks, so a new edition is therefore timely. At the same time, the teaching of evolutionary medicine has also been steadily gaining momentum both in courses that prepare undergraduates for medical school in North America and in other contexts worldwide. Evolutionary Medicine is intended for undergraduate students preparing for careers in medicine and public health, students in schools of medicine and public health, and medical professionals curious about the insights that evolutionary thinking can bring to their field. It will also be relevant to students and researchers in the fields of evolutionary biology, anthropology, developmental biology, and genetics. It highlights the most important insights in a relatively brief and compelling book that does not attempt encyclopedic coverage of a rapidly changing field.

A New York Times 2016 Notable Book The definitive history of the successful battle to halt the AIDS epidemic--from the creator of, and inspired by, the seminal documentary How to Survive a Plague. A riveting, powerful telling of the story of the grassroots movement of activists, many of them in a life-or-death struggle, who seized upon scientific research to help develop the drugs that turned HIV from a mostly fatal infection to a manageable disease. Ignored by public officials, religious leaders, and the nation at large, and confronted with shame and hatred, this small group of men and women chose to fight for their right to live by educating themselves and demanding to become full partners in the race for effective treatments. Around the globe, 16 million people are alive today thanks to their efforts. Not since the publication of Randy Shilts's classic And the Band Played On has a book measured the AIDS plague in such brutally human, intimate, and soaring terms. In dramatic fashion, we witness the founding of ACT UP and TAG (Treatment Action Group), and the rise of an underground drug market in opposition to the prohibitively expensive (and sometimes toxic) AZT. We watch as these activists learn to become their own researchers, lobbyists, drug smugglers, and clinicians, establishing their own newspapers, research journals, and laboratories, and as they go on to force reform in the nation's disease-fighting agencies. With his unparalleled access to this community David France illuminates the lives of extraordinary characters, including the closeted Wall Street trader-turned-activist, the high school dropout who found purpose battling pharmaceutical giants in New York, the South African physician who helped establish the first officially recognized buyers' club at the height of the epidemic, and the public relations executive fighting to save his own life for the sake of his young daughter. Expansive yet richly detailed, this is an insider's account of a pivotal moment in the history of American civil rights. Powerful, heart-wrenching, and finally exhilarating, How to Survive a Plague is destined to become an essential part of the literature of AIDS.

The word concussion used to be unheard of in youth sports a decade ago. The brain injury was indeed occurring, but coaches and parents were encouraging their youth athletes to "shake it off" after "getting their bell rung". Science and increased awareness about concussion are transforming the way youth parents, coaches, and players pursue athletics. Fear of incurring concussions, as well as incorrect information, is leading some parents to keep their children out of contact sports, such as football and soccer, where concussion is more prevalent.Back in the Game: Why Concussion Doesn't Have to End Your Athletic Career does not dwell on perpetuating fears, but rather, provides the most up-to-date understanding of the condition. This text includes a real-world discussion of what science and medicine knows, what parents and coaches need to understand about concussions, evaluation and treatment, and possible post-concussive issues, like depression. At the heart of this book, the authors delve into these issues, explaining them in a clear and understandable way.The expertise and experiences of noted sports neurologist Jeffrey Kutcher, MD, along with reporting and interviews by award-winning sports journalist Joanne C. Gerstner, makes this book a timely, relevant, and real discussion about concussions in youth sports. Athletes and professional coaches who have participated in the formation of this book include two-time Olympic gold medalist soccer player Kate Markgraf, former NHL/Team Canada head coach Andy Murray, champion X-Games snowboarder Ellery Hollingsworth, along with an array of youth parents, coaches, and athletes from across the country.

‘An absolute must read for anyone wanting to takeback control of their body and their diet, without needing a doctorate in chemistry.’ Psychologies 'Such a brilliant book.' Maureen Brookbanks, Daily Mail 'Utterly had me gasping and rethinking my relationship with food and what I advise my patients – just a fabulous book.' – Dr Nighat Arif, GP in women’s health, author and broadcaster –- Unpacking the truth about what’s on your plate – and what it’s doing to your health Everyone is talking about ultra-processed food (UPF) and its impact on our health – but what about women? Is this very modern way of eating having a unique and specific impact on the female body? Are these ‘industrially produced food-like items in plastic packets’ that many of us consume particularly damaging to women’s health? In Ultra-Processed Women, acclaimed journalist and women’s health advocate Milli Hill uncovers the shocking truth. From period pain and weight gain to depression, hormone imbalances, autoimmune conditions and even Alzheimer’s, Hill reveals cutting-edge research into the hidden dangers that lurk in your daily food choices. But this is not just a book about food. Ultra-Processed Women also explores the way the modern food industry has exploited women in their advertising for decades and uncovers the damage being wrought not only on our bodies but on the environment and on our own ability to connect with each other through the fundamentally human experience of cooking and eating. This isn’t just a wake-up call – it’s a battle cry. Written in Hill’s trademark down-to-earth style, Ultra-Processed Women will help you understand the issues and develop a clear course of action, arming you with tools and practical steps to cut through the confusion, break free from the damaging effects of UPFs, and reclaim your health without guilt or deprivation. Changing the way we eat, Hill argues, is a radical act of resistance to an ultra-processed world. It’s time to take back control. Your body, your choices, your future.