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The classic account of survivors of the sleeping-sickness during the great epidemic just after World War I—and their return to the world after decades of “sleep.” • From the distinguished neurologist and the bestselling author of The Man Who Mistook His Wife for a Hat“One of the most beautifully composed and moving works of our time." —The Washington PostAwakenings—which inspired the major motion picture starring Robert DeNiro and Robin Williams—is the remarkable story of a group of patients who contracted sleeping-sickness during the great epidemic just after World War I. Frozen for decades in a trance-like state, these men and women were given up as hopeless until 1969, when Dr. Oliver Sacks gave them the then-new drug L-DOPA, which had an astonishing, explosive, "awakening" effect. Dr. Sacks recounts the moving case histories of his patients, their lives, and the extraordinary transformations which went with their reintroduction to a changed world.

'Ground-breaking. Everyone should read this book' Bessel van der Kolk, author of The Body Keeps the ScoreWhen it comes to understanding the connection between our mental and physical health, we should be looking at the exceptions, not the rules.Dr Jeff Rediger, a world-leading Harvard psychiatrist, has spent the last fifteen years studying thousands of individuals from around the world, examining the stories behind extraordinary cases of recovery from terminal illness.Observing the common denominators of people who have beaten the odds, Dr Rediger reveals the immense power of our immune system and unlocks the secrets of the mind-body connection. In Cured, he explains the vital role that nutrition plays in boosting our immunity and fighting off disease, and he also outlines how stress, trauma and identity affect our physical health.In analysing the remarkable science of recovery, Dr Rediger reveals the power of our mind to heal our body and shows us the keys to good health.'In an era of incurable chronic diseases causing 60% of all deaths worldwide, this book provides one potential way out' Dr Mark Hyman, author of The Blood Sugar Solution'Seasoned with the author's penetrating insights about healing, clearly articulated science and illuminating case histories, Cured opens genuine vistas of transforming illness into health' Gabor Maté, author of When the Body Says No

If it weren't for mitochondria, scientists argue, we'd all still be single-celled bacteria. Indeed, these tiny structures inside our cells are important beyond imagining. Without mitochondria, we would have no cell suicide, no sculpting of embryonic shape, no sexes, no menopause, no aging.In this fascinating and thought-provoking book, Nick Lane brings together the latest research in this exciting field to show how our growing insight into mitochondria has shed light on how complex life evolved, why sex arose (why don't we just bud?), and why we age and die. These findings are of fundamental importance, both in understanding life on Earth, but also in controlling our own illnesses, and delaying our degeneration and death. Readers learn that two billion years ago, mitochondria were probably bacteria living independent lives and that their capture within larger cells was a turning point in the evolution of life, enabling the development of complex organisms. Lane describes how mitochondria have their own DNA and that its genes mutate much faster than those in the nucleus. This high mutation rate lies behind our aging and certain congenital diseases. The latest research suggests that mitochondria play a key role in degenerative diseases such as cancer. We also discover that mitochondrial DNA is passed down almost exclusively via the female line. That's why it has been used by some researchers to trace human ancestry daughter-to-mother, to "Mitochondrial Eve," giving us vital information about our evolutionary history.Written by Nick Lane, a rising star in popular science, Power, Sex, Suicide is the first book for general readers on the nature and function of these tiny, yet fascinating structures.

This book is about the discovery that the human brain has its own unique way of healing. For centuries we believed that the price we paid for our brain’s complexity was that, compared to other organs, it was fixed and unregenerative — unable to recover from damage or illness. In his revolutionary new book, Norman Doidge turns this belief on its head.The phenomenon of neuroplasticity — the discovery that the brain can change its own structure and function in response to mental experience — is the most important development in our understanding of the brain and mind since the beginning of modern science. Here, Doidge shows how the amazing process of neuroplastic healing really works. When it is understood, it is often possible to radically improve — and even cure — many conditions thought to be irreversible.Doidge introduces us to the doctors, therapists, and patients who are healing the brain without surgery or medication. We meet patients who have alleviated years of chronic pain; children on the autistic spectrum, or with ADD or learning disorders, who have used neuroplastic techniques to complete a normal education and become independent; and sufferers who have seen symptoms of multiple sclerosis, Parkinson’s disease, brain injuries, and cerebral palsy radically diminish; and we learn how to lower our risk of dementia by 60 per cent. Through hopeful, astonishing stories, The Brain’s Way of Healing explains how mind, brain, and body, and the energies around us, work together in health and healing.

#1 NEW YORK TIMES BESTSELLER • OPRAH’S BOOK CLUB PICK • ONE OF GQ's TOP 50 BOOKS OF LITERARY JOURNALISM IN THE 21st CENTURY • The heartrending story of a midcentury American family with twelve children, six of them diagnosed with schizophrenia, that became science's great hope in the quest to understand the disease."Reads like a medical detective journey and sheds light on a topic so many of us face: mental illness." —Oprah WinfreyDon and Mimi Galvin seemed to be living the American dream. After World War II, Don's work with the Air Force brought them to Colorado, where their twelve children perfectly spanned the baby boom: the oldest born in 1945, the youngest in 1965. In those years, there was an established script for a family like the Galvins--aspiration, hard work, upward mobility, domestic harmony--and they worked hard to play their parts. But behind the scenes was a different story: psychological breakdown, sudden shocking violence, hidden abuse. By the mid-1970s, six of the ten Galvin boys, one after another, were diagnosed as schizophrenic. How could all this happen to one family?What took place inside the house on Hidden Valley Road was so extraordinary that the Galvins became one of the first families to be studied by the National Institute of Mental Health. Their story offers a shadow history of the science of schizophrenia, from the era of institutionalization, lobotomy, and the schizophrenogenic mother to the search for genetic markers for the disease, always amid profound disagreements about the nature of the illness itself. And unbeknownst to the Galvins, samples of their DNA informed decades of genetic research that continues today, offering paths to treatment, prediction, and even eradication of the disease for future generations.With clarity and compassion, bestselling and award-winning author Robert Kolker uncovers one family's unforgettable legacy of suffering, love, and hope.

John Green, the #1 bestselling author of The Anthropocene Reviewed and a passionate advocate for global healthcare reform, tells a deeply human story illuminating the fight against the world’s deadliest disease.Tuberculosis has been entwined with humanity for millennia. Once romanticized as a malady of poets, today tuberculosis is seen as a disease of poverty that walks the trails of injustice and inequity we blazed for it.In 2019, author John Green met Henry Reider, a young tuberculosis patient at Lakka Government Hospital in Sierra Leone. John became fast friends with Henry, a boy with spindly legs and a big, goofy smile. In the years since that first visit to Lakka, Green has become a vocal advocate for increased access to treatment and wider awareness of the healthcare inequities that allow this curable, preventable infectious disease to also be the deadliest, killing over a million people every year.In Everything Is Tuberculosis, John tells Henry’s story, woven through with the scientific and social histories of how tuberculosis has shaped our world—and how our choices will shape the future of tuberculosis.

A NEW YORK TIMES BESTSELLERFrom a renowned behavioral neuroscientist and recovering addict, a rare page-turning work of science that draws on personal insights to reveal how drugs work, the dangerous hold they can take on the brain, and the surprising way to combat today's epidemic of addiction.Judith Grisel was a daily drug user and college dropout when she began to consider that her addiction might have a cure, one that she herself could perhaps discover by studying the brain. Now, after twenty-five years as a neuroscientist, she shares what she and other scientists have learned about addiction, enriched by captivating glimpses of her personal journey.In Never Enough, Grisel reveals the unfortunate bottom line of all regular drug use: there is no such thing as a free lunch. All drugs act on the brain in a way that diminishes their enjoyable effects and creates unpleasant ones with repeated use. Yet they have their appeal, and Grisel draws on anecdotes both comic and tragic from her own days of using as she limns the science behind the love of various drugs, from marijuana to alcohol, opiates to psychedelics, speed to spice.With more than one in five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide, and Grisel delves with compassion into the science of this scourge. She points to what is different about the brains of addicts even before they first pick up a drink or drug, highlights the changes that take place in the brain and behavior as a result of chronic using, and shares the surprising hidden gifts of personality that addiction can expose. She describes what drove her to addiction, what helped her recover, and her belief that a “cure” for addiction will not be found in our individual brains but in the way we interact with our communities.Set apart by its color, candor, and bell-clear writing, Never Enough is a revelatory look at the roles drugs play in all of our lives and offers crucial new insight into how we can solve the epidemic of abuse.

Describes the search for the genes that control cancer, explains the difficulties of research in molecular biology, and assesses progress towards a more detailed understanding of cancer

For nearly 40 years, Rosen’s Emergency Medicine has provided emergency physicians, residents, physician assistants, and other emergency medicine practitioners with authoritative, accessible, and comprehensive information in this rapidly evolving field. The fully revised 10th Edition delivers practical, evidence-based knowledge and specific recommendations from clinical experts in a clear, precise format, with focused writing, current references, and extensive use of illustrations to provide definitive guidance for emergency conditions. With coverage ranging from airway management and critical care through diagnosis and treatment of virtually every emergency condition, from highly complex to simple and common, this award-winning, two-volume reference remains your #1 choice for reliable, up-to-date information across the entire spectrum of emergency medicine practice. Offers the most immediately clinically relevant content of any emergency medicine resource, providing diagnostic and treatment recommendations and workflows with clear indications and preferred actions.  Contains eight entirely new chapters covering coronaviruses/COVID-19, the morbidly obese patient, human trafficking, sexual minority (LGBTQ) patients, social determinants of health, community violence, and humanitarian aid in war and crisis.   Features over 1,700 figures, including more than 350 new anatomy drawings, graphs and charts, algorithms, and photos.  Includes new information across the spectrum of emergency care, such as adult and pediatric airway management, shock, pandemic disease, emergency toxicology, sepsis syndrome, resuscitation, medical emergencies of pregnancy, the immunocompromised patient, child abuse, pediatric sedation, pediatric trauma, and more.  Features revised and refined chapter templates that enhance navigation, making it easy to find key information quickly.  Provides access to more than 1,200 questions and answers online to aid in exam preparation, as well as two dozen new video clips showing how to best perform critical emergency procedures in real time.  Reviewed and verified cover-to-cover by a team of expert clinical pharmacists to ensure accuracy and completeness of all drug information and treatment recommendations. 

**THE SUNDAY TIMES BESTSELLER**'You're amazing I could talk to you (Rahul) all day' Chris Evans'This is a gripping new book' The TimesWorld-leading neuroscientist and neurosurgeon Dr Rahul Jandial draws on his years of work with patients suffering from the most extreme cases of brain damage, disorders and illnesses to reveal what they can tell us about the science of the mind.From a languages teacher who has to choose whether to lose her ability to speak Spanish or English after brain surgery, to a former TV exec, now homeless, who discovers that his life-altering despondency is the result of a tumour, to a fainting teen who learns that deep breathing can mean the difference between life or death, these stories uncover the secret workings of the brain.Blending cutting-edge research and beautiful storytelling, Life Lessons from a Brain Surgeon is a vital resource on the best ways to boost your memory, control stress and emotions, minimize pain, unleash your creativity, raise smart kids and reduce the risk of Alzheimer's. This is a deeply practical and readable book, which will take you on an expedition through the anatomy of the most fascinating - and mysterious - of organs.