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'Ground-breaking. Everyone should read this book' Bessel van der Kolk, author of The Body Keeps the ScoreWhen it comes to understanding the connection between our mental and physical health, we should be looking at the exceptions, not the rules.Dr Jeff Rediger, a world-leading Harvard psychiatrist, has spent the last fifteen years studying thousands of individuals from around the world, examining the stories behind extraordinary cases of recovery from terminal illness.Observing the common denominators of people who have beaten the odds, Dr Rediger reveals the immense power of our immune system and unlocks the secrets of the mind-body connection. In Cured, he explains the vital role that nutrition plays in boosting our immunity and fighting off disease, and he also outlines how stress, trauma and identity affect our physical health.In analysing the remarkable science of recovery, Dr Rediger reveals the power of our mind to heal our body and shows us the keys to good health.'In an era of incurable chronic diseases causing 60% of all deaths worldwide, this book provides one potential way out' Dr Mark Hyman, author of The Blood Sugar Solution'Seasoned with the author's penetrating insights about healing, clearly articulated science and illuminating case histories, Cured opens genuine vistas of transforming illness into health' Gabor Maté, author of When the Body Says No

In this paradigm-shifting book from acclaimed Harvard Medical School doctor and one of TIME magazine's 100 most influential people on earth, Dr. David Sinclair reveals that everything we think we know about ageing is wrong, and shares the surprising, scientifically-proven methods that can help readers live younger, longer. For decades, the medical community has looked to a variety of reasons for why we age, and the consensus is that no one dies of old age; they die of age-related diseases. That's because ageing is not a disease - it is inevitable.But what if everything you think you know about ageing is wrong?What if ageing is a disease? And that disease is curable.In THE EVOLUTION OF AGEING, Dr. David Sinclair, one of the world's foremost authorities on genetics and ageing, argues just that. He has dedicated his life's work to chasing more than a longer lifespan - he wants to enable people to live longer, healthier, and disease-free well into our hundreds. In this book, he reveals a bold new theory of ageing, one that pinpoints a root cause of ageing that lies in an ancient genetic survival circuit. This genetic trick - a circuit designed to halt reproduction in order to repair damage to the genome -has enabled earth's early microcosms to survive and evolve into more advanced organisms. But this same survival circuit is the reason we age: as genetic damage accumulates over our lifespans from UV rays, environmental toxins, and unhealthy diets, our genome is overwhelmed, causing gray hair, wrinkles, achy joints, heart issues, dementia, and, ultimately, death.But genes aren't our destiny; we have more control over them than we've been taught to believe. We can't change our DNA, but we can harness the power of the epigenome to realise the true potential of our genes. Drawing on his cutting-edge findings at the forefront of medical research, Dr. Sinclair will provide a scientifically-proven roadmap to reverse the genetic clock by activating our vitality genes, so we can live younger longer. Readers will discover how a few simple lifestyle changes - like intermittent fasting, avoiding too much animal protein, limiting sugar, avoiding x-rays, exercising with the right intensity, and even trying cold therapy - can activate our vitality genes. Dr. Sinclair ends the book with a look to the near future, exploring what the world might look like - and what will need to change - when we are all living well to 120 or more.Dr. Sinclair takes what we have long accepted as the limits of human potential and mortality and turns them into choices. THE EVOLUTION OF AGEING is destined to be the biggest book on genes, biology, and longevity of this decade.

Reader-friendly Cell Biology, 4th Edition, provides a concise but comprehensive foundation for students entering research or health care career paths. Award winning illustrations help readers quickly grasp general principles. The authors have thoroughly updated this popular text to provide readers with the current understanding of the principles of normal cellular function along with examples of how molecular defects predispose to human disease. Major new themes in the 4th edition include the roles of intrinsically disordered polypeptides and phase separation in cellular functions, the influence of new molecular structures on understanding mechanisms, and the impact of exciting new methods―from single cell RNA sequencing to second generation super resolution fluorescence microscopy―on advancing our understanding.Clear, readable explanations provide a concise story about how cells function at the molecular level.An intuitive chapter flow starts with genome organization, gene expression, and RNA processing as a foundation for understanding every aspect of cellular function and physiology.Brings cellular biology to life for students interested in medical science by explaining how mutations in genes can compromise virtually every cellular system and predispose to human disease. Knowledge of cell biology has led to new treatments for cancer, heart failure, cystic fibrosis, and many other diseases.Unique illustrations with realistic proportions and relationships explain every cellular process including the assembly of SARS CoV-2, the structures attaching mitotic chromosomes to microtubules, the mechanism of DNA replication and how pumps, carriers and channels orchestrate physiological processes from synaptic transmission to cellular volume regulation.Covers exciting breakthroughs such as SMC motor proteins actively organizing chromosomal DNA, TOR kinases regulating metabolism, new types of immunotherapy for cancer treatment, mechanisms regulating fast axonal transport and their relation to neurodegenerative diseases, how completion of DNA replication sets the time for cells to enter mitosis, how a cascade of signals specifies the site of cell division, and newly understood pathways of normal and pathological cell death.Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

This "eye-opening and essential" book (Bill Gates) will transform how you see our biggest environmental problems—and explains how we can solve them. It’s become common to tell kids that they’re going to die from climate change. We are constantly bombarded by doomsday headlines that tell us the soil won’t be able to support crops, fish will vanish from our oceans, and that we should reconsider having children. But in this bold, radically hopeful book, data scientist Hannah Ritchie argues that if we zoom out, a very different picture emerges. In fact, the data shows we’ve made so much progress on these problems that we could be on track to achieve true sustainability for the first time in human history. Did you know that: Carbon emissions per capita are actually down Deforestation peaked back in the 1980s The air we breathe now is vastly improved from centuries ago And more people died from natural disasters a hundred years ago? Packed with the latest research, practical guidance, and enlightening graphics, this book will make you rethink almost everything you’ve been told about the environment. Not the End of the World will give you the tools to understand our current crisis and make lifestyle changes that actually have an impact. Hannah cuts through the noise by outlining what works, what doesn’t, and what we urgently need to focus on so we can leave a sustainable planet for future generations.       These problems are big. But they are solvable. We are not doomed. We can build a better future for everyone. Let’s turn that opportunity into reality.  

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In this landmark book of popular science, Daniel E. Lieberman—chair of the department of human evolutionary biology at Harvard University and a leader in the field—gives us a lucid and engaging account of how the human body evolved over millions of years, even as it shows how the increasing disparity between the jumble of adaptations in our Stone Age bodies and advancements in the modern world is occasioning this paradox: greater longevity but increased chronic disease.   The Story of the Human Body brilliantly illuminates as never before the major transformations that contributed key adaptations to the body: the rise of bipedalism; the shift to a non-fruit-based diet; the advent of hunting and gathering, leading to our superlative endurance athleticism; the development of a very large brain; and the incipience of cultural proficiencies. Lieberman also elucidates how cultural evolution differs from biological evolution, and how our bodies were further transformed during the Agricultural and Industrial Revolutions.   While these ongoing changes have brought about many benefits, they have also created conditions to which our bodies are not entirely adapted, Lieberman argues, resulting in the growing incidence of obesity and new but avoidable diseases, such as type 2 diabetes. Lieberman proposes that many of these chronic illnesses persist and in some cases are intensifying because of “dysevolution,” a pernicious dynamic whereby only the symptoms rather than the causes of these maladies are treated. And finally—provocatively—he advocates the use of evolutionary information to help nudge, push, and sometimes even compel us to create a more salubrious environment. (With charts and line drawings throughout.)

Bailey & Love's Short Practice of Surgery remains one of the world's pre-eminent medical textbooks, beloved by generations of surgeons, with lifetime sales in excess of one million copies.Now in its 25th edition, the content has been thoroughly revised and updated while retaining its traditional strengths. Under the stewardship of the eminent editorial team, comprising two editors with experience gained over previous editions and a third editor new to this edition, and in response to reader feedback, the content has been sub-divided into parts to ensure a logical sequence and grouping of related chapters throughout while the text features enthusiastically received in the last edition have been retained. The new edition opens with sections devoted to the underlying principles of surgical practice, investigation and diagnosis, and pre-operative care. These are followed by chapters covering all aspects of surgical trauma. The remainder of the book considers each of the surgical specialties in turn, from elective orthopaedics through skin, head and neck, breast and endocrine, cardiothoracic and vascular, to abdominal and genitourinary.Key features: Authoritative: emphasises the importance of effective clinical examination and soundly based surgical principles, while taking into account the latest developments in surgical practice.Updated: incorporates new chapters on a wide variety of topics including metabolic response to injury, shock and blood transfusion, and surgery in the tropics.Easy to navigate: related chapters brought together into clearly differentiated sections for the first time.Readable: preserves the clear, direct writing style, uncluttered by technical jargon, that has proved so popular in previous editions.User-friendly: numerous photographs and explanatory line diagrams, learning objectives, summary boxes, biographical footnotes, memorable anecdotes and full-colour presentation supplement and enhance the text throughout.Bailey and Love has a wide appeal to all those studying surgery, from undergraduate medical students to those in preparation for their postgraduate surgical examinations. In addition, its high standing and reputation for unambiguous advice also make it the first point of reference for many practising surgeons. The changes that have been introduced to the 25th edition will only serve to strengthen support for the text among all these groups.

A candid, feminist, and personal deep dive into the science and culture of pregnancy and motherhoodLike most first-time mothers, Angela Garbes was filled with questions when she became pregnant. What exactly is a placenta and how does it function? How does a body go into labor? Why is breast best? Is wine totally off-limits? But as she soon discovered, it’s not easy to find satisfying answers. Your obstetrician will cautiously quote statistics; online sources will scare you with conflicting and often inaccurate data; and even the most trusted books will offer information with a heavy dose of judgment. To educate herself, the food and culture writer embarked on an intensive journey of exploration, diving into the scientific mysteries and cultural attitudes that surround motherhood to find answers to questions that had only previously been given in the form of advice about what women ought to do—rather than allowing them the freedom to choose the right path for themselves.In Like a Mother, Garbes offers a rigorously researched and compelling look at the physiology, biology, and psychology of pregnancy and motherhood, informed by in-depth reportage and personal experience. With the curiosity of a journalist, the perspective of a feminist, and the intimacy and urgency of a mother, she explores the emerging science behind the pressing questions women have about everything from miscarriage to complicated labors to postpartum changes. The result is a visceral, full-frontal look at what’s really happening during those nine life-altering months, and why women deserve access to better care, support, and information.Infused with humor and born out of awe, appreciation, and understanding of the female body and its strength, Like a Mother debunks common myths and dated assumptions, offering guidance and camaraderie to women navigating one of the biggest and most profound changes in their lives.

**THE SUNDAY TIMES BESTSELLER**'You're amazing I could talk to you (Rahul) all day' Chris Evans'This is a gripping new book' The TimesWorld-leading neuroscientist and neurosurgeon Dr Rahul Jandial draws on his years of work with patients suffering from the most extreme cases of brain damage, disorders and illnesses to reveal what they can tell us about the science of the mind.From a languages teacher who has to choose whether to lose her ability to speak Spanish or English after brain surgery, to a former TV exec, now homeless, who discovers that his life-altering despondency is the result of a tumour, to a fainting teen who learns that deep breathing can mean the difference between life or death, these stories uncover the secret workings of the brain.Blending cutting-edge research and beautiful storytelling, Life Lessons from a Brain Surgeon is a vital resource on the best ways to boost your memory, control stress and emotions, minimize pain, unleash your creativity, raise smart kids and reduce the risk of Alzheimer's. This is a deeply practical and readable book, which will take you on an expedition through the anatomy of the most fascinating - and mysterious - of organs.

For readers of Atul Gawande and Paul Kalanithi, a palliative care doctor's breathtaking stories from 30 years spent caring for the dying.Modern medical technology is allowing us to live longer and fuller lives than ever before. And for the most part, that is good news. But with changes in the way we understand medicine come changes in the way we understand death. Once a familiar, peaceful, and gentle -- if sorrowful -- transition, death has come to be something from which we shield our eyes, as we prefer to fight desperately against it rather than accept its inevitability.Dr. Kathryn Mannix has studied and practiced palliative care for thirty years. In With the End in Mind , she shares beautifully crafted stories from a lifetime of caring for the dying, and makes a compelling case for the therapeutic power of approaching death not with trepidation, but with openness, clarity, and understanding.Weaving the details of her own experiences as a caregiver through stories of her patients, their families, and their distinctive lives, Dr. Mannix reacquaints us with the universal, but deeply personal, process of dying. With insightful meditations on life, death, and the space between them, With the End in Mind describes the possibility of meeting death gently, with forethought and preparation, and shows the unexpected beauty, dignity, and profound humanity of life coming to an end.