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In this paradigm-shifting book from acclaimed Harvard Medical School doctor and one of TIME magazine's 100 most influential people on earth, Dr. David Sinclair reveals that everything we think we know about ageing is wrong, and shares the surprising, scientifically-proven methods that can help readers live younger, longer. For decades, the medical community has looked to a variety of reasons for why we age, and the consensus is that no one dies of old age; they die of age-related diseases. That's because ageing is not a disease - it is inevitable.But what if everything you think you know about ageing is wrong?What if ageing is a disease? And that disease is curable.In THE EVOLUTION OF AGEING, Dr. David Sinclair, one of the world's foremost authorities on genetics and ageing, argues just that. He has dedicated his life's work to chasing more than a longer lifespan - he wants to enable people to live longer, healthier, and disease-free well into our hundreds. In this book, he reveals a bold new theory of ageing, one that pinpoints a root cause of ageing that lies in an ancient genetic survival circuit. This genetic trick - a circuit designed to halt reproduction in order to repair damage to the genome -has enabled earth's early microcosms to survive and evolve into more advanced organisms. But this same survival circuit is the reason we age: as genetic damage accumulates over our lifespans from UV rays, environmental toxins, and unhealthy diets, our genome is overwhelmed, causing gray hair, wrinkles, achy joints, heart issues, dementia, and, ultimately, death.But genes aren't our destiny; we have more control over them than we've been taught to believe. We can't change our DNA, but we can harness the power of the epigenome to realise the true potential of our genes. Drawing on his cutting-edge findings at the forefront of medical research, Dr. Sinclair will provide a scientifically-proven roadmap to reverse the genetic clock by activating our vitality genes, so we can live younger longer. Readers will discover how a few simple lifestyle changes - like intermittent fasting, avoiding too much animal protein, limiting sugar, avoiding x-rays, exercising with the right intensity, and even trying cold therapy - can activate our vitality genes. Dr. Sinclair ends the book with a look to the near future, exploring what the world might look like - and what will need to change - when we are all living well to 120 or more.Dr. Sinclair takes what we have long accepted as the limits of human potential and mortality and turns them into choices. THE EVOLUTION OF AGEING is destined to be the biggest book on genes, biology, and longevity of this decade.

A riveting medical mystery about a young woman’s quest to uncover the truth about her likely fatal genetic disorder that opens a window onto the exploding field of genomic medicine When Joselin Linder was in her twenties her legs suddenly started to swell. After years of misdiagnoses, doctors discovered a deadly blockage in her liver. Struggling to find  an explanation for her unusual condition, Joselin compared the medical chart of her father—who had died from a mysterious disease, ten years prior—with that of an uncle who had died under similarly strange circumstances. Delving further into the past, she discovered that her great-grandmother had displayed symptoms similar to hers before her death. Clearly, this was more than a fluke. Setting out to build a more complete picture of the illness that haunted her family, Joselin approached Dr. Christine Seidman, the head of a group of world-class genetic researchers at Harvard Medical School, for help. Dr. Seidman had been working on her family’s case for twenty years and had finally confirmed that fourteen of Joselin’s relatives carried something called a private mutation—meaning that they were the first known people to experience the baffling symptoms of a brand new genetic mutation. Here, Joselin tells the story of their gene: the lives it claimed and the future of genomic medicine with the potential to save those that remain.  Digging into family records and medical history, conducting interviews with relatives and friends, and reflecting on her own experiences with the Harvard doctor, Joselin pieces together the lineage of this deadly gene to write a gripping and unforgettable exploration of family, history, and love. A compelling chronicle of survival and perseverance, The Family Gene is an important story of a young woman reckoning with her father’s death, her own mortality, and her ethical obligations to herself and those closest to her.

"All women need to read this book."—Dave Asprey, author of The Bulletproof Diet"Groundbreaking solutions for the common hormonal struggles women face both on and off birth control."—Amy Medling, founder of PCOS Diva and author of Healing PCOSA natural, effective program for restoring hormone balance, normalizing your period, and reversing the harmful side effects of ‘The Pill’—for the millions of women who take it for acne, PMS, menstrual cramps, PCOS, Endometriosis, and many more reasons other than contraception.Out of the 100 million women—almost 11 million in the United States alone—who are on the pill, roughly 60 percent take it for non-contraceptive reasons like painful periods, endometriosis, PCOS, and acne. While the birth control pill is widely prescribed as a quick-fix solution to a variety of women’s health conditions, taking it can also result in other more serious and dangerous health consequences. Did you know that women on the pill are more likely to be prescribed an antidepressant? That they are at significantly increased risk for autoimmune disease, heart attack, thyroid and adrenal disorders, and even breast and cervical cancer? That the pill can even cause vaginal dryness, unexplained hair loss, flagging libido, extreme fatigue, and chronic infection. As if women didn’t have enough to worry about, that little pill we’re taking to manage our symptoms is only making things worse.Jolene Brighten, ND, author of the groundbreaking new book Beyond the Pill, specializes in treating women’s hormone imbalances caused by the pill and shares her proven 30-day program designed to reverse the myriad of symptoms women experience every day—whether you choose to stay on the pill or not. The first book of its kind to target the birth control pill and the scientifically-proven symptoms associated with taking it, Beyond the Pill is an actionable plan for taking control, and will help readers: Locate the root cause of their hormonal issues, like estrogen dominance, low testosterone, and low progesterone Discover a pain-free, manageable period free of cramps, acne, stress, or PMS without the harmful side effects that come with the pill Detox the liver, support the adrenals and thyroid, heal the gut, reverse metabolic mayhem, boost fertility, and enhance mood Transition into a nutrition and supplement program, with more than 30 hormone-balancing recipesFeaturing simple diet and lifestyle interventions, Beyond the Pill is the first step to reversing the risky side effects of the pill, finally finding hormonal health, and getting your badass self back.

An examination of the contemporary medicalization of death and dying that calls us to acknowledge instead death's existential and emotional realities. Death is a natural, inevitable, and deeply human process, and yet Western medicine tends to view it as a medical failure. In their zeal to prevent death, physicians and hospitals often set patients and their families on a seemingly unstoppable trajectory toward medical interventions that may actually increase suffering at the end of life. This volume in the MIT Press Essential Knowledge series examines the medicalization of death and dying and proposes a different approach--one that acknowledges death's existential and emotional realities. The authors--one an academic who teaches and studies end-of-life care, and the other a physician trained in hospice and palliative care--offer an account of Western-style death and dying that is informed by both research and personal experience. They examine the medical profession's attitude toward death as a biological dysfunction that needs fixing; describe the hospice movement, as well as movements for palliative care and aid in dying, and why they failed to influence mainstream medicine; consider our reluctance to have end-of-life conversations; and investigate the commodification of medicine and the business of dying. To help patients die in accordance with their values, they say, those who care for the dying should focus less on delaying death by any means possible and more on being present with the dying on their journey.

“Overdosed America reveals the greed and corruption that drive health care costs skyward and now threaten the public health. Before you see a doctor, you should read this book.” —Eric Schlosser, author of Fast Food Nation Using the examples of Vioxx, Celebrex, cholesterol-lowering statin drugs, and anti-depressants, Overdosed America shows that at the heart of the current crisis in American medicine lies the commercialization of medical knowledge itself For twenty years, John Abramson, M.D., cared for patients of all ages in a small town north of Boston. But increasingly his role as family doctor was undermined as pressure mounted to use the latest drugs and high-tech solutions for nearly every problem. Drawing on his background in statistics and health policy research, he began to investigate the radical changes that were quietly taking place in American medicine. At the heart of the crisis, he found, lies the changed purpose of medical knowledge—from seeking to optimize health to searching for the greatest profits. The lack of transparency that has become normal in commercially sponsored medical research now taints the scientific evidence published in even our most prestigious medical journals. And unlike the recent scandals in other industries that robbed Americans of money and jobs, this one is undermining our health. Commercial distortion pervades the information that doctors rely upon to guide the prevention and treatment of common health problems, from heart disease to stroke, osteoporosis, diabetes, and osteoarthritis. The good news, as Dr. Abramson explains, is that the real scientific evidence shows that many of the things that you can do to protect and preserve your own health are far more effective than what the drug companies' top-selling products can do for you—which is why the drug companies work so hard to keep this information under wraps. In what is sure to be one of the most important and eye-opening books you or your doctor will ever read, John Abramson offers conclusive evidence that American medicine has broken its promise to best improve our health and is squandering more than $500 billion each year in the process.

Our microbiome - the complex ecosystem of bacteria, viruses and other microbes inside us - is critically important to our health and wellbeing. It is given to us by our mothers at birth, adapts with us as we age, influences our mood and appetites, determines how fast we run and even affects who we choose as a partner. In this ground-breaking book, expert on the microbiome James Kinross, takes us on a guided tour of our extraordinary inner universe, showing how our relationship with microbes may hold the key to why we are increasingly succumbing to diseases such as Alzheimer's, cancer and autoimmune conditions. He highlights the disastrous consequences of our war on germs, the effects of globalisation and our addiction to antibiotics, showing how it is only now, as we are beginning to discover the microbiome's enormous potential, that we are realising it is in grave danger. Drawing on cutting-edge research and years of clinical experience, Kinross shows us how to protect this vital inner world before it's too late - providing practical tips on how to optimise the microbiome to protect your health, boost your immunity and safeguard your mental wellbeing. His illuminating, urgent book shows that if we work with, not against our microbes, we can live better, healthier lives.

“Getting tuberculosis in the middle of your life is like starting downtown to do a lot of urgent errands and being hit by a bus. When you regain consciousness you remember nothing about the urgent errands. You can’t even remember where you were going.” Thus begins Betty MacDonald’s memoir of her year in a sanatorium just outside Seattle battling the “White Plague.” MacDonald uses her offbeat humor to make the most of her time in the TB sanatorium—making all of us laugh in the process.

Science journalist Sally Adee breaks open the field of bioelectricity—the electric currents that run through our bodies and every living thing—its misunderstood history, and why new discoveries will lead to new ways around antibiotic resistance, cleared arteries, and new ways to combat cancer. You may be familiar with the idea of our body's biome: the bacterial fauna that populate our gut and can so profoundly affect our health. In We Are Electric we cross into new scientific understanding: discovering your body's electrome. Every cell in our bodies—bones, skin, nerves, muscle—has a voltage, like a tiny battery. It is the reason our brain can send signals to the rest of our body, how we develop in the womb, and why our body knows to heal itself from injury. When bioelectricity goes awry, illness, deformity, and cancer can result. But if we can control or correct this bioelectricity, the implications for our health are remarkable: an undo switch for cancer that could flip malignant cells back into healthy ones; the ability to regenerate cells, organs, even limbs; to slow aging and so much more. The next scientific frontier might be decrypting the bioelectric code, much the way we did the genetic code. Yet the field is still emerging from two centuries of skepticism and entanglement with medical quackery, all stemming from an 18th-century scientific war about the nature of electricity between Luigi Galvani (father of bioelectricity, famous for shocking frogs) and Alessandro Volta (inventor of the battery). In We Are Electric, award-winning science writer Sally Adee takes readers through the thrilling history of bioelectricity and into the future: from the Victorian medical charlatans claiming to use electricity to cure everything from paralysis to diarrhea, to the advances helped along by the giant axons of squids, and finally to the brain implants and electric drugs that await us—and the moral implications therein.  The bioelectric revolution starts here.

'A work of exhilarating scope and relevance ... What a rare and powerful experience to feel a book in your very body' Naomi Klein'Health is not something we can attain as individuals, for ourselves, hermetically sealed off from the world around us. An injury to one is an injury to all.' Our bodies, societies and planet are inflamed. In this boldly original book, renowned political economist Raj Patel teams up with physician Rupa Marya to illuminate the hidden relationships between human health and the profound injustices of our political and economic systems. In doing so, they offer a radical new cure: the deep medicine of decolonization. Journeying through the human body - our digestive, endocrine, circulatory, respiratory, reproductive, immune, and nervous systems - Marya and Patel show how inflammation is connected not just to the food that we eat, the air that we breathe and access to healthcare, but is also linked to the traumatic events we experience and the very model of health that doctors practice: one which takes things apart, rather than seeking to bring ideas and lived experiences together. Combining the latest scholarship on globalization and biology with the stories of patients in marginalized communities and the wisdom of Indigenous groups, Inflamed points the way toward a medicine that heals what has been divided and has the potential to transform not only our bodies but the world.